Document Detail

Optimization of oxygen transport in mechanically ventilated newborns using oximetry and pulsed Doppler-derived cardiac output.
MedLine Citation:
PMID:  3048899     Owner:  NLM     Status:  MEDLINE    
In respiratory distress syndrome (RDS), PEEP improves arterial oxygenation but may impair cardiac output. The effects of PEEP on gas exchange and hemodynamics were studied in 12 mechanically ventilated newborns in the acute phase of RDS. Stepwise increase in PEEP resulted in both a) a progressive increase in PaO2 and transcutaneous oxyhemoglobin saturation, and b) a depression of pulsed Doppler-measured cardiac output that was statistically significant at 9 cm H2O PEEP. Thus, averaged systemic oxygen delivery (DO2) was maintained with improved arterial oxygenation up to 6 cm H2O PEEP. Further increase in PEEP induced a significant fall in DO2. No variation was observed in heart rate and mean arterial pressure. The combined use of oximetry and pulsed Doppler echocardiography enables noninvasive optimization of mechanical ventilation and PEEP during the clinical course.
T T Trang; J Tibballs; J C Mercier; F Beaufils
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  16     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1988-11-23     Completed Date:  1988-11-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1094-7     Citation Subset:  AIM; IM    
Service de Reánimatation Pédiatrique, Hôpital Robert Debre, Paris, France.
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MeSH Terms
Acute Disease
Blood Gas Monitoring, Transcutaneous*
Cardiac Output*
Echocardiography, Doppler
Infant, Newborn
Oxygen / blood*
Positive-Pressure Respiration / adverse effects*
Respiratory Distress Syndrome, Newborn / blood*,  physiopathology,  therapy
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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