| Optimization of nutritional requirements and feeding strategies for clavulanic acid production by Streptomyces clavuligerus. | |
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MedLine Citation:
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PMID: 17011778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present work reports the nutritional requirements and environmental conditions for submerged culture of Streptomyces clavuligerus for clavulanic acid production using orthogonal matrix method (Taguchi L(16) design) and also fed-batch fermentation for clavulanic acid production by feeding glycerol, arginine and threonoine to the fermentation medium intermittently. Clavulanic acid production was increased by 18% with the span of feeding glycerol and reached a maximum at 1.30mg/ml with 120h glycerol feeding as compared to 1.10mg/ml in the control. The production also increased with the span of feeding amino acids and reached a maximum of 1.31 and 1.86mg/ml with feeding arginine and threonine, respectively in 120h. There was an overall increase of 18% and 9% in clavulanic acid production with arginine and threonine feeding as compared to the respective controls (1.10 and 1.70mg/ml, respectively). |
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Authors:
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Parag S Saudagar; Rekha S Singhal |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2006-10-02 |
Journal Detail:
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Title: Bioresource technology Volume: 98 ISSN: 0960-8524 ISO Abbreviation: Bioresour. Technol. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-02-14 Completed Date: 2007-07-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9889523 Medline TA: Bioresour Technol Country: England |
Other Details:
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Languages: eng Pagination: 2010-7 Citation Subset: IM |
Affiliation:
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Food Engineering and Technology Department, Institute of Chemical Technology, University of Mumbai, Matunga, Mumbai 400 019, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arginine
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metabolism Bacteriological Techniques Clavulanic Acid / biosynthesis*, chemistry Culture Media Fermentation Glycerol / metabolism Phosphates / metabolism Streptomyces / metabolism* Threonine / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 0/Phosphates; 56-81-5/Glycerol; 58001-44-8/Clavulanic Acid; 72-19-5/Threonine; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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