Document Detail

Optimization of nutrient parameters for lovastatin production by Monascus purpureus MTCC 369 under submerged fermentation using response surface methodology.
MedLine Citation:
PMID:  17019609     Owner:  NLM     Status:  MEDLINE    
Lovastatin, an inhibitor of HMG-CoA reductase, was produced by submerged fermentation using Monascus purpureus MTCC 369. Five nutritional parameters screened using Plackett-Burman experimental design were optimized by Box-Behnken factorial design of response surface methodology for lovastatin production in shake flask cultures. Maximum lovastatin production of 351 mg/l were predicted in medium containing 29.59 g/l dextrose, 3.86 g/l NH4Cl, 1.73 g/l KH2PO4, 0.86 g/l MgSO4 x 7H2O, and 0.19 g/l MnSO4 x H2O using response surface plots and point prediction tool of DESIGN EXPERT 7.0 (Statease, USA) software.
Sadik Ali Sayyad; Bibhu Prasad Panda; Saleem Javed; Mohd Ali
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Publication Detail:
Type:  Journal Article     Date:  2006-09-22
Journal Detail:
Title:  Applied microbiology and biotechnology     Volume:  73     ISSN:  0175-7598     ISO Abbreviation:  Appl. Microbiol. Biotechnol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-20     Completed Date:  2007-08-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406612     Medline TA:  Appl Microbiol Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1054-8     Citation Subset:  IM    
Pharmaceutical Biotechnology Laboratory, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, 110062, India.
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MeSH Terms
Culture Media / chemistry
Lovastatin / biosynthesis*
Monascus / metabolism*
Reg. No./Substance:
0/Culture Media; 75330-75-5/Lovastatin

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