Document Detail


Optimization of magnetization transfer experiments for kinetic rate measurements.
MedLine Citation:
PMID:  7841025     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A framework is developed for optimizing magnetization transfer experiments for measuring first-order rate constants of a two-component exchange network. In the analysis the spin-lattice relaxation time of the nonsaturated resonance is assumed to be known. However, we demonstrate that our work can also be applied to cases in which the spin-lattice relaxation time falls within a physiologically reasonable range for this parameter. We provide an algorithm for the parameters permitting the experimenter to optimize the selection of measurement times in order to control the error in a worst-case scenario. In addition, we compare the performance of the time-dependent saturation experiment with an inversion experiment in this framework, finding that the former always leads to a more effective design.
Authors:
H Taitelbaum; G H Weiss; R G Spencer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  NMR in biomedicine     Volume:  7     ISSN:  0952-3480     ISO Abbreviation:  NMR Biomed     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-03-03     Completed Date:  1995-03-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8915233     Medline TA:  NMR Biomed     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  287-92     Citation Subset:  IM    
Affiliation:
Division of Computer Research and Technology, National Institutes of Health, Bethesda, MD 20892.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Animals
Kinetics
Magnetic Resonance Spectroscopy*
Magnetics*
Mathematics
Models, Biological*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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