Document Detail

Optimization of a formulation containing viable lactic acid bacteria.
MedLine Citation:
PMID:  12695017     Owner:  NLM     Status:  MEDLINE    
In the present study, gastric juice resistant tablet formulations of lactic acid bacteria (LAB) were developed, using hydroxypropylmethylcellulose acetate succinate (HPMCAS) as well as alginates, apple pectin and Metolose as matrix forming components. To optimize the formulation-using survival rate in acid medium, and disintegration time in intestinal fluid as test parameters-tablets were modified with respect to LAB content, amount of applied excipients per tablet, and compaction forces. A decrease of viable cells of not more than one log unit after 2h of incubation in acid medium was desired, as well as a disintegration time of 1h in phosphate buffer pH 6.8. It was found that the amount of HPMCAS in the tablet correlates with gastric juice resistance. As HPMCAS also leads to a decrease of disintegration time in intestinal fluid, slight amounts of this excipient were preferred. The best protective qualities against artificial gastric juice were observed when tablets were prepared from compaction mixtures of LAB, HPMCAS and sodium alginate.
M Stadler; H Viernstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  256     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-15     Completed Date:  2003-08-01     Revised Date:  2006-04-13    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  117-22     Citation Subset:  IM    
Institute of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstrasse 14, A-1090, Vienna, Austria.
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MeSH Terms
Colony Count, Microbial
Compressive Strength
Drug Compounding / methods
Drug Stability
Drug Storage
Excipients / chemistry
Gastric Juice / chemistry
Hydrogen-Ion Concentration
Lactic Acid / chemistry*
Lactobacillus acidophilus* / isolation & purification
Methylcellulose / analogs & derivatives*,  chemistry
Probiotics / chemistry*
Tablets, Enteric-Coated
Reg. No./Substance:
0/Excipients; 0/Tablets, Enteric-Coated; 50-21-5/Lactic Acid; 71138-97-1/hydroxypropylmethylcellulose acetate succinate; 9004-67-5/Methylcellulose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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