| Optimization of a formulation containing viable lactic acid bacteria. | |
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MedLine Citation:
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PMID: 12695017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study, gastric juice resistant tablet formulations of lactic acid bacteria (LAB) were developed, using hydroxypropylmethylcellulose acetate succinate (HPMCAS) as well as alginates, apple pectin and Metolose as matrix forming components. To optimize the formulation-using survival rate in acid medium, and disintegration time in intestinal fluid as test parameters-tablets were modified with respect to LAB content, amount of applied excipients per tablet, and compaction forces. A decrease of viable cells of not more than one log unit after 2h of incubation in acid medium was desired, as well as a disintegration time of 1h in phosphate buffer pH 6.8. It was found that the amount of HPMCAS in the tablet correlates with gastric juice resistance. As HPMCAS also leads to a decrease of disintegration time in intestinal fluid, slight amounts of this excipient were preferred. The best protective qualities against artificial gastric juice were observed when tablets were prepared from compaction mixtures of LAB, HPMCAS and sodium alginate. |
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Authors:
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M Stadler; H Viernstein |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 256 ISSN: 0378-5173 ISO Abbreviation: Int J Pharm Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-04-15 Completed Date: 2003-08-01 Revised Date: 2006-04-13 |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 117-22 Citation Subset: IM |
Affiliation:
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Institute of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstrasse 14, A-1090, Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Colony Count, Microbial Compressive Strength Drug Compounding / methods Drug Stability Drug Storage Excipients / chemistry Gastric Juice / chemistry Hydrogen-Ion Concentration Lactic Acid / chemistry* Lactobacillus acidophilus* / isolation & purification Methylcellulose / analogs & derivatives*, chemistry Probiotics / chemistry* Solubility Tablets, Enteric-Coated Temperature |
| Chemical | |
Reg. No./Substance:
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0/Excipients; 0/Tablets, Enteric-Coated; 50-21-5/Lactic Acid; 71138-97-1/hydroxypropylmethylcellulose acetate succinate; 9004-67-5/Methylcellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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