Document Detail


Optimization for enhancement of signal effectiveness in three-dimensional (3D) cell based electrochemical biosensor.
MedLine Citation:
PMID:  22256300     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study addresses the optimization for enhancement of signal effectiveness in 3D cell based electrochemical biosensor. While 2D culture has a structural limitation to mimic an in vivo, 3D culture can provide more similar cell responses. In addition, although 3D cultured cells have been applied to measure electrically, the intensity of electrical signal from cells on the electrode was extremely low. Thus, we have optimized and evaluated the condition of gelation between several types of sol-gel and cancer cells using the electrical measurement to make fine 3D cell structure on the electrode. These results show that our work can be an useful method for monitoring cell activity by compensating a limitation of 2D culture in real time.
Authors:
Se Hoon Jeong; Bosung Ku; Sang Hyun Yi; Dong Woo Lee; Hye Seon Lee; Jhingook Kim
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2011     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2011  
Date Detail:
Created Date:  2012-01-18     Completed Date:  2012-05-31     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8416-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biosensing Techniques / instrumentation*,  methods*
Cell Count
Cell Line, Tumor
Electricity
Electrochemical Techniques / instrumentation*,  methods*
Electrodes
Fluorescence
Humans
Imaging, Three-Dimensional / methods*
Signal Processing, Computer-Assisted*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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