Document Detail


Optimization of donor specific blood transfusion in kidney transplantation.
MedLine Citation:
PMID:  2978891     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. One hundred milliliters of stored whole blood DST, three times at weekly intervals is a practical, less immunizing and effective approach to enhance graft survival in recipients of a living-related donor kidney. 2. This protocol could also be used in sibling donor/recipient pairs who do not share a haplotype as well as in those who share two haplotypes to enhance graft survival. 3. The use of a short course of Cs (6 mg/kg/d for three weeks) along with DST appears to reduce the sensitization rate even lower. The dose of Cs used in this study produced no clinically significant adverse reactions, whereas Aza (1 mg/kg/d) often produces leukopenia. 4. DST produces significantly suppressed donor specific MLC responses in the early post-DST period; however, it increases the response at a later time. DST modulates immune responses in such a way that secondary responses upon grafting are more readily reversible by immunosuppressive agents.
Authors:
J S Cheigh; M Suthanthiran; W T Stubenbord; M Fotino; R R Riggio; N Schechter; K H Stenzel; A L Rubin
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  19     ISSN:  0041-1345     ISO Abbreviation:  Transplant. Proc.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1990-07-25     Completed Date:  1990-07-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2250-1     Citation Subset:  IM    
Affiliation:
Rogosin Kidney Center, New York Hospital/Cornell University Medical College, NY.
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MeSH Terms
Descriptor/Qualifier:
Adult
B-Lymphocytes / immunology
Blood Donors
Blood Transfusion*
Clinical Trials as Topic
Cytotoxicity Tests, Immunologic
Female
Graft Rejection
Graft Survival
Haplotypes
Histocompatibility Testing
Humans
Immunosuppression / methods
Kidney Transplantation / immunology*
Lymphocyte Culture Test, Mixed
Male
Prospective Studies
T-Lymphocytes / immunology
Tissue Donors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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