| Optimization of donor specific blood transfusion in kidney transplantation. | |
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MedLine Citation:
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PMID: 2978891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. One hundred milliliters of stored whole blood DST, three times at weekly intervals is a practical, less immunizing and effective approach to enhance graft survival in recipients of a living-related donor kidney. 2. This protocol could also be used in sibling donor/recipient pairs who do not share a haplotype as well as in those who share two haplotypes to enhance graft survival. 3. The use of a short course of Cs (6 mg/kg/d for three weeks) along with DST appears to reduce the sensitization rate even lower. The dose of Cs used in this study produced no clinically significant adverse reactions, whereas Aza (1 mg/kg/d) often produces leukopenia. 4. DST produces significantly suppressed donor specific MLC responses in the early post-DST period; however, it increases the response at a later time. DST modulates immune responses in such a way that secondary responses upon grafting are more readily reversible by immunosuppressive agents. |
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Authors:
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J S Cheigh; M Suthanthiran; W T Stubenbord; M Fotino; R R Riggio; N Schechter; K H Stenzel; A L Rubin |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Transplantation proceedings Volume: 19 ISSN: 0041-1345 ISO Abbreviation: Transplant. Proc. Publication Date: 1987 Feb |
Date Detail:
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Created Date: 1990-07-25 Completed Date: 1990-07-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2250-1 Citation Subset: IM |
Affiliation:
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Rogosin Kidney Center, New York Hospital/Cornell University Medical College, NY. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult B-Lymphocytes / immunology Blood Donors Blood Transfusion* Clinical Trials as Topic Cytotoxicity Tests, Immunologic Female Graft Rejection Graft Survival Haplotypes Histocompatibility Testing Humans Immunosuppression / methods Kidney Transplantation / immunology* Lymphocyte Culture Test, Mixed Male Prospective Studies T-Lymphocytes / immunology Tissue Donors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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