Document Detail

Optimization of coronary perfusion rate during cardiac surgery in man.
MedLine Citation:
PMID:  431099     Owner:  NLM     Status:  MEDLINE    
Myocardial oxygen consumption (Vo2) and lactate flux were measured in 12 patients with aortic valve disease and left ventricular hypertrophy during cardiac surgery with hypothermic cardiopulmonary bypass and artificial coronary perfusion. Coronary flow was varied from "standard" flow-defined as giving a "line pressure" of 110 mm. Hg-to 25 or 50 percent higher than standard flow. Lactate flux was not significant at any flow. Vo2 was higher at +25 percent flow that at standard flow, but no significant further increase in Vo2 occurred at +50 percent. Myocardial Q10 and coronary vascular resistance also approached optimal values at a flow of +25 percent, corresponding with a mean coronary flow of 203 ml. times min -1. The difficulties are discussed of standardizing coronary perfusion in useful practical terms.
E A Harris; K N Parimelazhagan; E R Seelye; B G Barratt-Boyes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  77     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-06-29     Completed Date:  1979-06-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  662-8     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Flow Velocity
Cardiac Surgical Procedures / methods*
Cardiopulmonary Bypass / methods*
Coronary Circulation*
Lactates / metabolism
Middle Aged
Myocardium / metabolism
Oxygen Consumption
Regression Analysis
Vascular Resistance
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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