| Optimization of contrast agent volume for helical CT in the diagnostic assessment of patients with severe and multiple injuries. | |
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MedLine Citation:
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PMID: 11801913 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The aim of this study was to determine the optimal amount of contrast agent for helical CT of the trunk during primary radiologic evaluation of polytraumatized patients. METHOD: Eighty-three patients with severe and multiple injuries (mean age 36.2 years) underwent standardized helical CT examination with administration of a single contrast agent bolus of iohexol (Accupaque 300) at volumes of 120, 150, and 180 ml. Image quality was estimated by two blinded radiologists using a visual analogue scale. Analysis further included density measurements in regions of interest (ROIs) placed in the ascending, descending, and abdominal aorta as well as in the liver and spleen. RESULTS: The qualitative rating of the contrast agent effect after administration of 150 and 180 ml was significantly better compared with 120 ml [odds ratio (OR) 12.05, 95% confidence interval (CI) 3.50-41.52 and OR 12.14, 95% CI 3.36-43.85, respectively]. A dose increase from 120 to 150 ml resulted in a significantly better enhancement of the abdominal aorta (p = 0.006). The highest dose of 180 ml was not associated with a diagnostic gain in the other ROIs. CONCLUSION: We recommend administration of 150 ml of iohexol as the optimal amount of contrast material for single phase bolus administration in emergency helical CT examination of the chest and abdomen. |
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Authors:
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Grit Rademacher; Dirk Stengel; Stefanie Siegmann; Jan Petersein; Sven Mutze |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of computer assisted tomography Volume: 26 ISSN: 0363-8715 ISO Abbreviation: J Comput Assist Tomogr Publication Date: 2002 Jan-Feb |
Date Detail:
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Created Date: 2002-01-21 Completed Date: 2002-02-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7703942 Medline TA: J Comput Assist Tomogr Country: United States |
Other Details:
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Languages: eng Pagination: 113-8 Citation Subset: IM |
Affiliation:
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Department of Radiology, Unfallkrankenhaus Berlin, Germany. grit.rademacher@ukb.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Injuries
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radiography Adult Contrast Media* / administration & dosage Female Humans Iohexol / administration & dosage, diagnostic use* Male Multiple Trauma / radiography* Thoracic Injuries / radiography Tomography, X-Ray Computed / methods* Trauma Severity Indices |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 66108-95-0/Iohexol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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