Document Detail


Optimization of bioactive compounds in buckwheat sprouts and their effect on blood cholesterol in hamsters.
MedLine Citation:
PMID:  18217700     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nutrient levels in buckwheats that were maximized in day 8 sprouts (D8SP) included total phenolics, quercetin, and l-ascorbic acid, whereas those of oxalic, malic, tartaric, and citric acids, rutin, and gamma-aminobutyric acid (GABA) were found to reach maximum levels on day 10. Ethanolic extract of D8SP (2.5 mg/mL) revealed potent free-radical scavenging (FRS) and antioxidative (ANO) capabilities. However, its Fe2+-chelating capability was only moderate. To further study the hypolipidemic activity of D8SP, 36 Syrian hamsters were grouped into six groups and fed for 28 days, respectively, with (i) control meal, (ii) high fat plus high cholesterol meal, (iii) high fat plus high cholesterol plus 2.5% of buckwheat seeds, (iv) high fat plus high cholesterol plus 25% of buckwheat seeds, (v) high fat plus high cholesterol plus 2.5% of D8SP, and (vi) high fat plus high cholesterol plus 25% of D8SP. High seed meal prominently enhanced body weight gain, whereas high sprout meal exhibited the highest feed efficiency. Ratios of liver/body weight (L/B) were significantly lowered by all BS meals. Although low seed meal reduced serum total cholesterol (TC) levels (p<0.05), its effect was still inferior to the high seed and sprout meals (p<0.01). In contrast, serum triglyceride (TG) levels were lowered only by the high seed and sprout meals (p<0.05). Alternatively, levels of serum low-density lipoprotein cholesterol (LDL-C) were significantly suppressed by all buckwheat meals (p<0.01). Serum high-density lipoprotein cholesterol (HDL-C) levels were increased, however, insignificantly. Nutraceutically more meaningful is that both LDL-C/HDL-C and TC/HDL-C ratios were significantly lowered (p<0.01). Apparently, hepatic TC levels were significantly reduced, whereas hepatic TG levels were totally unaffected. Conclusively, sprouting triggers a variety of nutritional changes in buckwheats. Day 8 sprouts, consisting of high polyphenolic and moderate quercetin contents, are nutraceutically maximized when hypocholesterolemic, hypotriglyceridemic, and antioxidative activities are concerned.
Authors:
Li-Yun Lin; Chiung-Chi Peng; Ya-Lu Yang; Robert Y Peng
Publication Detail:
Type:  Journal Article     Date:  2008-01-24
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  56     ISSN:  0021-8561     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-21     Completed Date:  2008-04-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1216-23     Citation Subset:  IM    
Affiliation:
Department of Food and Nutrition, Hungkuang University, Shalu County, Taichung Hsien, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Aminobutyric Acids / analysis
Animals
Antilipemic Agents / pharmacology*
Ascorbic Acid / analysis
Cholesterol / blood
Cricetinae
Fagopyrum / chemistry*
Fatty Acids / analysis
Flavonoids / analysis
Food Analysis / methods*
Free Radical Scavengers
Germination
Hyperlipidemias / drug therapy*
Phenols / analysis
Phytotherapy*
Plant Extracts / pharmacology*
Quercetin / analysis
Random Allocation
Rutin / analysis
Seeds / chemistry
Triglycerides / blood
Weight Gain
Chemical
Reg. No./Substance:
0/Aminobutyric Acids; 0/Antilipemic Agents; 0/Fatty Acids; 0/Flavonoids; 0/Free Radical Scavengers; 0/Phenols; 0/Plant Extracts; 0/Triglycerides; 0/polyphenols; 117-39-5/Quercetin; 153-18-4/Rutin; 50-81-7/Ascorbic Acid; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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