| Optimization of the Selective Preparation of 20(R)-Ginsenoside Rg3 Catalyzed by D, L-Tartaric Acid Using Response Surface Methodology. | |
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MedLine Citation:
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PMID: 23219978 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The optimization of the selective preparation of 20(R)-ginsenoside Rg3 converting protopanaxadiol type saponins (PPD saponins) by the commercially available D, L-tartaric acid was carried out using response surface methodology (RSM) based on a three-factor and six-level central composite design. The optimal 20(R)-ginsenoside Rg3 de% was predicted to be 94.52% in the combination of the factors (D, L-tartaric acid concentration 1.19 mol/L, temperature 107.9 °C and time 2.79 h) through the canonical analysis with maximum responses. Under the optimum reaction conditions, the actual 20(R)-ginsenoside Rg3 de% was 96.49%. 20(R)-ginsenoside Rg3 (1) and 20(S)-ginsenoside Rg3 (2) were separated and identified by (1)H-NMR and (13)C-NMR. Therefore, the RSM was effective to optimize the preparation of 20(R)-ginsenoside Rg3 by converting PPD saponins using D, L-tartaric acid. |
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Authors:
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Chengpeng Sun; Weiping Gao; Baozhong Zhao; Leqin Cheng |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-3 |
Journal Detail:
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Title: Fitoterapia Volume: - ISSN: 1873-6971 ISO Abbreviation: Fitoterapia Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 16930290R Medline TA: Fitoterapia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier B.V. |
Affiliation:
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Department of Chemistry, Northeast Normal University, Changchun, P. R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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