| Optimising contrast-enhanced cranial CT for detection of brain metastases. | |
| | |
MedLine Citation:
|
PMID: 9817049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: In order to optimise contrast-enhanced CT in the detection of brain metastases, we investigated how sensitivity was affected by an increase in contrast medium dose and a reduction in slice thickness. MATERIAL AND METHODS: A total of 198 cases of known primary malignancy with suspected brain metastases were investigated in three consecutive contrast-enhanced CT examinations. The first was a standard CT examination with an injection of 100 ml contrast medium (300 mg I/ml) and a slice thickness of 10 mm. A further 100 ml contrast medium was given and the second examination was performed immediately afterwards with the same slice thickness as the first. This was followed by the third examination, which used a slice thickness of 5 mm. The standard contrast-enhanced CT images were compared with the double-dose images and with the images of reduced slice thickness (5 mm instead of 10 mm). RESULTS: The double-dose images demonstrated an 8-18% increase in the number of brain metastases detected compared to the standard contrast-enhanced CT; the images of the 5-mm-thick slices showed a further 22-33% increase. The comparison between the standard contrast-enhanced CT images and the images with both thinner slices and the double dose of contrast medium demonstrated a 32-55% increase in the number of metastases detected. CONCLUSION: A considerable increase in sensitivity (32-55%) in contrast-enhanced CT can be obtained by reducing the slice thickness and increasing the contrast medium dose. This optimised technique should be the method of choice in patients with known primary malignancy and suspected brain metastases. |
| | |
Authors:
|
V Sighvatsson; K Ericson; H Tómasson |
Related Documents
:
|
1592599 - Indications for gadolinium-dtpa in magnetic resonance evaluation of extracranial head a... 6847429 - Computed tomography in acute cerebral multiple sclerosis. a report of two cases. 11149089 - Ct imaging of splenic sequestration in sickle cell disease. 10369979 - Screening applications for mri in the detection of upper abdominal disease: comparative... 22470769 - Intraosseous schwannoma of the petrous apex. 3875999 - Contrast enhancement in ct differentiation between recurrent disk herniation and postop... 19088689 - The evolution in the use of mibg in more than 25 years of experimental and clinical app... 22509949 - Computed tomography assessment of pharmacological lung volume reduction induced by bron... 17492289 - Two k versus 4 k storage phosphor chest radiography: detection performance and image qu... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Acta radiologica (Stockholm, Sweden : 1987) Volume: 39 ISSN: 0284-1851 ISO Abbreviation: Acta Radiol Publication Date: 1998 Nov |
Date Detail:
|
Created Date: 1998-12-01 Completed Date: 1998-12-01 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8706123 Medline TA: Acta Radiol Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 718-22 Citation Subset: IM |
Affiliation:
|
Department of Neuroradiology, Karolinska Hospital, Stockholm, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Brain Neoplasms / radiography*, secondary* Contrast Media / administration & dosage* Follow-Up Studies Humans Injections, Intravenous Iohexol / administration & dosage, diagnostic use* Middle Aged Radiographic Image Enhancement / methods* Retrospective Studies Sensitivity and Specificity Skull / radiography* Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 66108-95-0/Iohexol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Shear stress in cerebral arteries carrying saccular aneurysms. A preliminary study.
Next Document: Embolotherapy for pulmonary arteriovenous malformations in patients with hereditary hemorrhagic tela...