Document Detail

Optimising acid inhibition treatment.
MedLine Citation:
PMID:  16335855     Owner:  NLM     Status:  MEDLINE    
Acid inhibition is safe and useful in several clinical settings. Proton pump inhibitors are more effective than H2-receptor antagonists in virtually all cases. Proton pump inhibitors should be used in: the eradication of Helicobacter pylori; the treatment of non-H. pylori-related peptic ulcer healing; for the prevention and treatment of non-steroidal anti-inflammatory drug-induced upper digestive lesions; for bleeding peptic lesions; and, especially, in the short-term and long-term control of gastro-oesophageal reflux disease. The timing, the dosing and the specific drugs should be adapted to the particular patient, clinical situation and local factors. For instance, in a patient with active bleeding from a duodenal ulcer, intravenous constant infusion should be the preferred treatment. When seeking oral 'potent' acid inhibition (refractory gastro-oesophageal reflux disease, and perhaps Barrett's oesophagus), available data suggest that the pharmacological and clinical profiles of esomeprazole are slightly better.
Fernando Gomollón; Xavier Calvet
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drugs     Volume:  65 Suppl 1     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  2005  
Date Detail:
Created Date:  2005-12-12     Completed Date:  2005-12-23     Revised Date:  2013-01-07    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  25-33     Citation Subset:  IM    
Facultad de Medicina, Gastroenterology Service, Clinical University Hospital, Zaragoza, Spain.
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MeSH Terms
Anti-Ulcer Agents / administration & dosage*
Esomeprazole Sodium / administration & dosage*
Gastric Acid / secretion*
Peptic Ulcer / drug therapy*
Proton Pumps / antagonists & inhibitors*
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Proton Pumps; L2C9GWQ43H/Esomeprazole Sodium

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