| Optimised radiological diagnosis of hepatic fungal infection during the treatment of leukemia. | |
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MedLine Citation:
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PMID: 22320220 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Hepatic fungal infection is a frequent complication in patients receiving intensive chemotherapy for acute leukaemia. Hepatic lesions may be detected using computerised tomographic (CT) scans, but there is no standardised CT protocol for the diagnosis and follow-up of hepatic fungal infection. We therefore retrospectively analysed the number and the volume of hepatic fungal lesions in 24 CT of 20 consecutive patients treated for acute leukaemia during late-arterial and porto-venous phase. The mean number of lesions per patient was 31 (range: 3-105) in the late-arterial and 26 (3-81) in the porto-venous CT (P = 0.026). The mean total volume of all lesions was 6.45 ml in the late-arterial and 4.07 ml in the porto-venous CT representing a 1.6fold difference between the two CT scans (P = 0.008). The total volume of the lesions negatively correlated to the absolute contrast difference between liver parenchyma and liver vein (Pearson correlation, r = -0.62; P = 0.002). In conclusion, the late-arterial CT provides a superior distinction of hepatic lesions due to a delayed perfusion of the outer rim of the fungal lesions resulting in an extended visibility. The late-arterial CT is superior to the porto-venous CT for initial diagnosis and follow-up of hepatic fungal infection. |
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Authors:
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Ulf Petrausch; Thomas Frauenfelder; Nicolas J Mueller; Kornelius Arn; Georg Stussi; Urs Schanz |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-10 |
Journal Detail:
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Title: Mycoses Volume: - ISSN: 1439-0507 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8805008 Medline TA: Mycoses Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Blackwell Verlag GmbH. |
Affiliation:
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Clinic of Immunology, University Hospital Zurich, Zurich, Switzerland Department of Medical Radiology, Institute of Diagnostic Radiology, University Hospital Zurich, Zurich, Switzerland Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland Department of Internal Medicine, Clinic of Hematology, University Hospital Zurich, Zurich, Switzerland Divison of Hematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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