Document Detail

Optimal timing of revascularization: transmural versus nontransmural acute myocardial infarction.
MedLine Citation:
PMID:  11308159     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Higher mortality for emergency coronary artery bypass grafting (CABG) after an acute myocardial infarction (AMI) is well established. Whether it applies to both transmural and nontransmural AMI is unclear. This information may have different therapeutic implications for each cohort of patients. METHODS: A retrospective multicenter analysis of 44,365 patients who underwent CABG after myocardial infarction between 1993 and 1996 by 179 surgeons at 32 hospitals in New York State was performed. RESULTS: Overall hospital mortality for all patients with or without AMI was 2.5% versus 3.1% for patients who underwent CABG with history of myocardial infarction. Hospital mortality decreased with increasing time interval between CABG and AMI; 11.8%, 9.5%, and 2.8% (p < 0.001 for all values) for less than 6 hours, 6 hours to 1 day, and greater than 1 day, respectively. Patients with transmural and nontransmural AMI had identical mortality of 3.1%. However, different patterns emerged when comparing these two groups of patients with respect to time of operation. Mortality was higher in the transmural group if CABG was performed within 7 days after AMI. Multivariate analysis confirmed that CABG within 1 day and 6 hours of AMI are independent risk factors for mortality in the transmural and nontransmural groups, respectively. CONCLUSIONS: Early operation after transmural AMI has a significantly higher risk, and surgeons should be prepared to provide aggressive cardiac support including left ventricular assist devices in this ailing population. Waiting in some may be warranted.
D C Lee; M C Oz; A D Weinberg; S X Lin; W Ting
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  71     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-18     Completed Date:  2001-05-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1197-202; discussion 1202-4     Citation Subset:  AIM; IM    
Department of Surgery, Columbia University College of Physicians and Surgeons, New York, New York, USA.
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MeSH Terms
Aged, 80 and over
Cohort Studies
Coronary Artery Bypass / methods,  mortality*
Emergency Treatment
Hospital Mortality / trends*
Logistic Models
Middle Aged
Multicenter Studies as Topic
Myocardial Infarction / mortality*,  pathology,  surgery*
Myocardial Revascularization / methods
Reference Values
Retrospective Studies
Survival Analysis
Time Factors
Treatment Outcome
United States / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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