Document Detail


Optimal timing of electrical cardioversion in patients with persistent atrial fibrillation.
MedLine Citation:
PMID:  20885349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Many studies have tried to propose risk factors for atrial fibrillation recurrence after a successful pharmacological or electrical cardioversion. Regarding the duration of atrial fibrillation before electrical cardioversion, only limited data exist. The aim of our study was to investigate the effect of atrial fibrillation duration on long-term sinus rhythm maintenance in patients after successful electrical cardioversion of persistent atrial fibrillation.
MATERIAL/METHODS: Three hundred one patients after successful electrical cardioversion were included in the analysis. The patients were followed for 2 years. Electrocardiogram showing atrial fibrillation was considered the study endpoint.
RESULTS: After mean observational time of 377±311 days, atrial fibrillation occurred in 168 patients (61.5%). Multivariate logistic regression analysis showed the duration of atrial fibrillation was the only predictor of atrial fibrillation recurrence (OR 1.06; CI 1.00-1.11; P=.036), while amiodarone appeared to protect against atrial fibrillation recurrence OR 0.26; CI 0.07-0.95; P=.041). A Cox proportional hazards multivariate model predicted atrial fibrillation recurrence rate of atrial fibrillation ≥10 months (OR 1.87, CI 1.26 to 2.76, P=.002) and treatment with amiodarone (OR 0.55, CI 0.40-0.76, P=.000).
CONCLUSIONS: Atrial fibrillation duration before electric cardioversion is a significant predictor of atrial fibrillation recurrence rate after successful restoration of sinus rhythm. Further studies are needed to clarify the implications of atrial fibrillation duration on sinus rhythm persistence after a successful cardioversion.
Authors:
Franjo Naji; Damijan Vokac; Vojko Kanic; Miso Sabovic
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  16     ISSN:  1643-3750     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-04-18     Revised Date:  2011-06-14    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  CR464-8     Citation Subset:  IM    
Affiliation:
Department of Cardiology and Angiology, University Medical Centre, Maribor, Slovenia. franjo.naji@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Amiodarone / therapeutic use
Anti-Arrhythmia Agents / therapeutic use
Atrial Fibrillation / drug therapy,  physiopathology,  therapy*
Electric Countershock*
Electrocardiography
Female
Humans
Logistic Models
Male
Middle Aged
Predictive Value of Tests
Proportional Hazards Models
Recurrence / prevention & control
Retrospective Studies
Risk Factors
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 1951-25-3/Amiodarone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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