| Optimal surgical management of severe ischemic mitral regurgitation: To repair or to replace? | |
| | |
MedLine Citation:
|
PMID: 22054660 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Ischemic mitral regurgitation, a complication of myocardial infarction and coronary artery disease more generally, is associated with a high mortality rate and is estimated to affect 2.8 million Americans. With 1-year mortality rates as high as 40%, recent practice guidelines of professional societies recommend repair or replacement, but there remains a lack of conclusive evidence supporting either intervention. The choice between therapeutic options is characterized by the trade-off between reduced operative morbidity and mortality with repair versus a better long-term correction of mitral insufficiency with replacement. The long-term benefits of repair versus replacement remain unknown, which has led to significant variation in surgical practice. METHODS AND RESULTS: This article describes the design of a prospective randomized clinical trial to evaluate the safety and effectiveness of mitral valve repair and replacement in patients with severe ischemic mitral regurgitation. This trial is being conducted as part of the Cardiothoracic Surgical Trials Network. This article addresses challenges in selecting a feasible primary end point, characterizing the target population (including the degree of mitral regurgitation) and analytical challenges in this high mortality disease. CONCLUSIONS: The article concludes by discussing the importance of information on functional status, survival, neurocognition, quality of life, and cardiac physiology in therapeutic decision making. |
| | |
Authors:
|
Louis P Perrault; Alan J Moskowitz; Irving L Kron; Michael A Acker; Marissa A Miller; Keith A Horvath; Vinod H Thourani; Michael Argenziano; David A D'Alessandro; Eugene H Blackstone; Claudia S Moy; Joseph P Mathew; Judy Hung; Timothy J Gardner; Michael K Parides |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-3 |
Journal Detail:
|
Title: The Journal of thoracic and cardiovascular surgery Volume: - ISSN: 1097-685X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved. |
Affiliation:
|
Department of Surgery, Montreal Heart Institute, University of Montréal, Montréal, Québec, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Predictors and impact of postoperative atrial fibrillation on patients' outcomes: A report from the ...
Next Document: Transcatheter aortic valve implantation versus surgical aortic valve replacement: A propensity score...