Document Detail


Optimal strategies for familial searching.
MedLine Citation:
PMID:  25082141     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Familial searching is the process of finding potential relatives of the donor of a crime scene profile in a DNA database. Several authors have proposed strategies for generating candidate lists of potential relatives. This paper reviews four strategies and investigates theoretical properties as well as empirical behavior, using a comprehensive simulation study on mock databases. The effectiveness of a familial search is shown to highly depend on the case profile as well as on the tuning parameters. We give recommendations for proceeding in an optimal way and on how to choose tuning parameters both in general and on a case-by-case basis. Additionally we treat searching heterogeneous databases (not all profiles comprise the same loci) and composite searching for multiple types of kinship. An R-package for reproducing results in a particular case is released to help decision-making in familial searching.
Authors:
Maarten Kruijver; Ronald Meester; Klaas Slooten
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-12
Journal Detail:
Title:  Forensic science international. Genetics     Volume:  13C     ISSN:  1878-0326     ISO Abbreviation:  Forensic Sci Int Genet     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-8-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101317016     Medline TA:  Forensic Sci Int Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  90-103     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
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