Document Detail

Optimal management of pregnant women with acute venous thromboembolism.
MedLine Citation:
PMID:  10629417     Owner:  NLM     Status:  MEDLINE    
Venous thromboembolism (VTE) is an important cause of obstetric morbidity and mortality. Its management during pregnancy is problematic because anticoagulants, the cornerstone of initial therapy for VTE, may have significant foetal as well as maternal side effects. Unfractionated heparin has been the anticoagulant of choice in pregnancy; however, there is growing clinical experience with low-molecular-weight heparin (LMWH) in this patient population. A recently published systematic review of the literature suggests that the use of LMWH during pregnancy is not associated with adverse foetal/infant outcomes. Moreover, its long-term use appears to be safe for the mother, as symptomatic osteoporosis, bleeding and heparin- induced thrombocytopenia occurred only infrequently. There are limited data regarding the efficacy of anticoagulant therapy in the treatment of VTE during pregnancy, and treatment recommendations have largely been extrapolated from data in non-pregnant patients and case series of pregnant patients. This paper will briefly review the challenges and areas of controversy associated with the use of anticoagulants in the treatment of pregnancy-associated VTE.
S M Bates
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Haemostasis     Volume:  29 Suppl S1     ISSN:  0301-0147     ISO Abbreviation:  Haemostasis     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-25     Completed Date:  2000-02-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0371574     Medline TA:  Haemostasis     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  107-11     Citation Subset:  IM    
Copyright Information:
Copyright 1999 S. Karger AG, Basel
Department of Medicine, McMaster University and Hamilton Civic Hospitals Research Center, Hamilton, Ont., Canada.
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MeSH Terms
Anticoagulants / therapeutic use*
Heparin / therapeutic use
Heparin, Low-Molecular-Weight / therapeutic use
Pregnancy Complications, Cardiovascular / drug therapy*
Venous Thrombosis / drug therapy*
Reg. No./Substance:
0/Anticoagulants; 0/Heparin, Low-Molecular-Weight; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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