| Optimal management of chronic hepatitis B patients with treatment failure and antiviral drug resistance. | |
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MedLine Citation:
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PMID: 23286855 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The management of treatment failure in patients with chronic hepatitis B, remains a clinical concern. Incomplete viral suppression and the emergence of drug resistance are key determinants of treatment failure. The correct choice of a potent first-line therapy to achieve sustained long-term suppression of viral replication provides the best chance of preventing treatment failure and drug resistance. Clinical studies have demonstrated that drugs with a high barrier to resistance have significantly lower rates of resistance compared with those with a low barrier to resistance. Management of treatment failure requires precise clinical and virological monitoring as well as early treatment intervention with appropriate noncross-resistant antivirals. Long-term surveillance of treatment efficacy and possible emergence of drug resistance is necessary in patients who have been sequentially treated with multiple antivirals. The identification of novel treatment targets remains a major research goal to improve the efficacy of current antiviral therapy through combination therapy regimens. |
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Authors:
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Fabien Zoulim; Stephen Locarnini |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Liver international : official journal of the International Association for the Study of the Liver Volume: 33 Suppl 1 ISSN: 1478-3231 ISO Abbreviation: Liver Int. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101160857 Medline TA: Liver Int Country: United States |
Other Details:
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Languages: eng Pagination: 116-24 Citation Subset: IM |
Copyright Information:
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© 2012 John Wiley & Sons A/S. |
Affiliation:
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INSERM, U1052, Cancer Research Center of Lyon, Lyon University, Lyon, France; Hepatology Department, Hospices Civils de Lyon, Lyon, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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