Document Detail


Optimal length of smooth muscle assessed by a microstructurally and statistically based constitutive model.
MedLine Citation:
PMID:  21161795     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Smooth muscle exhibits an optimal length at which it is able to generate a maximum amount of force. In this study, the optimal length is assessed by use of a microstructurally and statistically based constitutive model for smooth muscle. The model is based on the sliding filament theory, and a modified version of Hill's mechanical model was adopted. It was conjectured, that a variation in the overlap in the actomyosin contractile units together with a statistical dispersion in the size of the dense bodies are responsible for the optimal length characteristics. The influence of contractile unit length, dense body size and dense body compliance was investigated, and the model was fully able to predict experimental data. The results indicate that the compliance of the dense bodies does not contribute significantly to the total compliance of the contractile apparatus.
Authors:
M Kroon
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Publication Detail:
Type:  Journal Article     Date:  2010-12-01
Journal Detail:
Title:  Computer methods in biomechanics and biomedical engineering     Volume:  14     ISSN:  1476-8259     ISO Abbreviation:  Comput Methods Biomech Biomed Engin     Publication Date:  2011  
Date Detail:
Created Date:  2011-01-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9802899     Medline TA:  Comput Methods Biomech Biomed Engin     Country:  England    
Other Details:
Languages:  eng     Pagination:  43-52     Citation Subset:  IM    
Affiliation:
Department of Solid Mechanics, Royal Institute of Technology, Stockholm, SE, Sweden.
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