| Optimal interaction of respiratory and thermal regulation at rest and during exercise: role of a serotonin-gated spinoparabrachial thermoafferent pathway. | |
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MedLine Citation:
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PMID: 19770073 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent evidence indicates that the lateral parabrachial nucleus (LPBN) in dorsolateral pons is pivotal in mediating the feedback control of inspiratory drive by central chemoreceptor input and feedforward control of body temperature by cutaneous thermoreceptor input. The latter is subject to descending serotonergic inhibition which gates the transmission of ascending thermoafferent information from spinal dorsal horn to the LPBN. Here, a model is proposed which suggests that the LPBN may be important in balancing respiratory and thermal homeostasis, two conflicting goals that are heightened by environmental heat/cold stress or exercise where the effects of respiratory thermolysis become prominent. This optimization model of respiratory-thermoregulatory interaction is supported by a host of recent studies which demonstrate that animals with serotonin (5-HT) dysfunction at the spinal dorsal horn--due to 5-HT antagonism, genetic 5-HT defects or spinal cord injury--all display similar respiratory abnormalities that are consistent with hyperactivity of the spinoparabrachial thermoafferent (and pain) pathway. |
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Authors:
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Chi-Sang Poon |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2009-09-19 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 169 ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-25 Completed Date: 2010-02-24 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 234-42 Citation Subset: IM |
Affiliation:
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Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Bldg E25-250, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. cpoon@mit.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Afferent Pathways
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physiology Animals Body Temperature Regulation / physiology* Exercise / physiology* Humans Models, Biological Pons / physiology* Respiration Rest* Serotonin / genetics, metabolism* Spinal Cord / physiology* Spinal Cord Injuries / genetics, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HL067966/HL/NHLBI NIH HHS; HL072849/HL/NHLBI NIH HHS; HL079503/HL/NHLBI NIH HHS; R01 HL067966-05A2/HL/NHLBI NIH HHS; R01 HL072849-04/HL/NHLBI NIH HHS; R01 HL079503-04/HL/NHLBI NIH HHS; R01 HL079503-04S1/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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