| Optimal follicle and oocyte numbers for cryopreservation of all embryos in IVF cycles at risk of OHSS. | |
| | |
MedLine Citation:
|
PMID: 18765000 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Ovarian hyperstimulation syndrome (OHSS) is a rare but potentially fatal complication of IVF treatment. The risk of OHSS increases with increasing numbers of follicles aspirated and oocytes retrieved, but there is little evidence to support whether threshold values of either can be used to correctly predict OHSS. Since the most severe forms of OHSS are usually associated with pregnancy, cryopreservation of all embryos may prevent this. The authors attempted to find thresholds of follicle and oocyte numbers that would optimally predict OHSS, through a retrospective analysis of 2253 consecutive cycles of IVF/intracytoplasmic sperm injection treatment reaching oocyte retrieval, between 1 January 2003 and 31 March 2006. Receiver operator characteristic (ROC) curves were calculated for both parameters, to determine threshold values that might predict OHSS in women with > or =20 oocytes. For the prediction of early onset OHSS, ROC curves showed that an optimal balance between sensitivity and specificity was achieved using thresholds of 24 oocytes (79%, 60%) and 29 follicles (82%, 65%) respectively. Using these thresholds, cryopreservation of all embryos may be offered as an alternative to cancellation of a treatment cycle due to excessive ovarian response, thus minimizing the number of unnecessary interventions while still correctly predicting most cases of early onset OHSS. |
| | |
Authors:
|
Gideon R Verwoerd; Thomas Mathews; Peter R Brinsden |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Reproductive biomedicine online Volume: 17 ISSN: 1472-6491 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2008 Sep |
Date Detail:
|
Created Date: 2008-09-03 Completed Date: 2008-10-31 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: England |
Other Details:
|
Languages: eng Pagination: 312-7 Citation Subset: IM |
Affiliation:
|
Assisted Conception Unit, Bourn Hall Clinic, Bourn, Cambridge, UK. gideon.verwoerd@lcg-bourn.co.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cryopreservation* Embryo, Mammalian* Female Fertilization in Vitro / methods Humans Oocytes / cytology* Ovarian Follicle / cytology* Ovarian Hyperstimulation Syndrome / etiology* Pregnancy ROC Curve Retrospective Studies Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Luteal phase oestradiol suppression by letrozole: a pilot study in oocyte donors.
Next Document: Progesterone supplementation during cryopreserved embryo transfer cycles: efficacy and convenience o...