Document Detail


Optimal fentanyl dosage for attenuating systemic hemodynamic changes, hormone release and cardiac output changes during the induction of anesthesia in patients with and without hypertension: a prospective, randomized, double-blinded study.
MedLine Citation:
PMID:  23314694     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: The purpose of this study was to compare the dose-related effects of fentanyl on systemic hemodynamics, hormone release and cardiac output in response to endotracheal intubation in patients with and without hypertension. METHODS: Forty-five patients without hypertension and 45 patients with hypertension (total 90 patients) undergoing elective general surgical, urological or gynecological procedures under general anesthesia were studied. The patients were randomly divided into three groups to receive either saline (control), 2.0 μg/kg fentanyl or 4.0 μg/kg fentanyl before tracheal intubation. Anesthesia was induced via intravenous target controlled infusion of propofol (plasma concentration, 4.0 μg/mL) followed by administration of the three drugs. Heart rate, blood pressure, and cardiac output were continuously monitored using Flo Trac/Vigileo system™ and Bispectral index from before anesthetic induction until 10 min after tracheal intubation. RESULTS: In patients without hypertension, there was a significant difference in mean arterial pressure (MAP) among the three groups 2 min after intubation. Cardiac index (CI) in all three groups decreased before intubation compared with that in the awake period, returning to awake values after intubation in all three groups. There was a significant difference in CI between the 4 μg/kg fentanyl group and the other two groups immediately and 1 min after intubation. In patients with hypertension, a differential time course of MAP changes was observed among the three groups after intubation. CI in the three groups decreased after the induction of anesthesia and increased after intubation in control and 2 μg/kg fentanyl groups compared with that in the awake period. CONCLUSIONS: The present study shows that it is preferable to administer 2 μg/kg fentanyl in patients without hypertension and 4 μg/kg fentanyl in patients with hypertension in order to minimize the changes in heart rate, systolic blood pressure and cardiac output associated with tracheal intubation.
Authors:
Yukari Sawano; Masumi Miyazaki; Hitoshi Shimada; Yuji Kadoi
Related Documents :
6524274 - Respiratory depression after epidural morphine in the postoperative period. influence o...
11167434 - Phaeochromocytoma: an unusual cause of hypertension in pregnancy.
23805424 - Wound hematoma after anterior cervical spine surgery: in vitro study of the pathophysio...
9350374 - Midazolam reverses histamine-induced bronchoconstriction in dogs.
998434 - Comparison of the effects of prostaglandins a, e, f, and b on the canine pulmonary vasc...
22623444 - Why critical limb ischemia criteria are not applicable to diabetic foot and what the co...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-12
Journal Detail:
Title:  Journal of anesthesia     Volume:  -     ISSN:  1438-8359     ISO Abbreviation:  J Anesth     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8905667     Medline TA:  J Anesth     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Anesthesia, Tomioka General Hospital, Maebashi, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparing immediate transient tinnitus suppression using tACS and tDCS: a placebo-controlled study.
Next Document:  Effects of IgM-Enriched Immunoglobulin Therapy in Septic-Shock-Induced Multiple Organ Failure: Pilot...