Document Detail


Optimal exercise program length for patients with claudication.
MedLine Citation:
PMID:  22459748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: This prospective, randomized controlled clinical trial determined whether an optimal exercise program length exists to efficaciously change claudication onset time (COT) and peak walking time (PWT) in patients with peripheral artery disease and claudication.
METHODS: The study randomized 142 patients to supervised exercise (n = 106) or a usual care control group (n = 36), with 80 completing the exercise program and 27 completing the control intervention. The exercise program consisted of intermittent walking to nearly maximal claudication pain 3 days per week. COT and PWT were the primary outcomes obtained from a treadmill exercise test at baseline and bimonthly during the study.
RESULTS: After exercise, changes in COT (P < .001) and PWT (P < .001) were consistently greater than changes after the control intervention. In the exercise program, COT and PWT increased from baseline to month 2 (P < .05) and from months 2 to 4 (P < .05) but did not significantly change from months 4 to 6 (P > .05). When changes were expressed per mile walked during the first 2 months, middle 2 months, and final 2 months of exercise, COT and PWT only increased during the first 2 months (P < .05).
CONCLUSIONS: Exercise-mediated gains in COT and PWT occur rapidly within the first 2 months of exercise rehabilitation and are maintained with further training. The clinical significance is that a relatively short 2-month exercise program may be preferred to a longer program to treat claudication because adherence is higher, costs associated with personnel and use of facilities are lower per patient, and more patients can be trained for a given amount of personnel time and resource utilization.
Authors:
Andrew W Gardner; Polly S Montgomery; Donald E Parker
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-03-28
Journal Detail:
Title:  Journal of vascular surgery     Volume:  55     ISSN:  1097-6809     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-30     Completed Date:  2012-06-20     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1346-54     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00654810
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MeSH Terms
Descriptor/Qualifier:
Aged
Baltimore
Chi-Square Distribution
Exercise Test
Exercise Therapy*
Exercise Tolerance
Female
Humans
Intermittent Claudication / etiology,  physiopathology,  therapy*
Male
Middle Aged
Patient Compliance
Peripheral Arterial Disease / complications,  physiopathology,  therapy*
Prospective Studies
Questionnaires
Recovery of Function
Regional Blood Flow
Time Factors
Treatment Outcome
Walking
Grant Support
ID/Acronym/Agency:
K01 AG000657/AG/NIA NIH HHS; K01 AG000657-05/AG/NIA NIH HHS; K01-00657//PHS HHS; P60 AG012583/AG/NIA NIH HHS; P60 AG012583-05/AG/NIA NIH HHS; P60-AG12583/AG/NIA NIH HHS; R01 AG024296/AG/NIA NIH HHS; R01 AG024296-01A2/AG/NIA NIH HHS; R01-AG-24296/AG/NIA NIH HHS
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