| Optimal erythrocyte ribavirin level to reduce the risk of anemia and obtain an early virological response in patients with chronic hepatitis C caused by genotype 1b infection. | |
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MedLine Citation:
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PMID: 21151503 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aims. To determine whether the erythrocyte phosphorylated ribavirin (RBV) level might be a useful index of EVR and risk of anemia and to determine the optimal dose of RBV in 24 patients with hepatitis C with pegylated interferon and RBV. Methodology. The RBV level was measured by a high-performance liquid chromatography. Results and Conclusion. In patients aged 50 years or over, a negative correlation (r = -0.548, P < .05) was observed between the RBV level at week 2 and rate of Hb reduction (ΔHb) at week 4. The ΔHb at week 4 was significantly greater in patients with RBV levels of ≥800 μM (-25.5 ± 10.1%) than in patients with RBV levels <800 μM (-15.6 ± 7.7%). None of the patients with RBV levels <600 μM at week 2 achieved EVR and SVR. Thus the optimal levels of erythrocyte phosphorylated RBV at week 2 of therapy in order to achieve EVR without anemia seemed to be 600-800 μM. |
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Authors:
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Rie Kubota; Takako Komiyama; Naoki Kumagai; Miyuki Kimijima; Keiko Mitsuki; Junko Uetake; Fumihiko Kaneko; Satoshi Tsunematsu; Kanji Tsuchimoto |
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Publication Detail:
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Type: Journal Article Date: 2010-09-08 |
Journal Detail:
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Title: Hepatitis research and treatment Volume: 2010 ISSN: 2090-1372 ISO Abbreviation: Hepat Res Treat Publication Date: 2010 |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101542600 Medline TA: Hepat Res Treat Country: United States |
Other Details:
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Languages: eng Pagination: 495928 Citation Subset: - |
Affiliation:
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Pharmacy Practice and Sciences, Department of Clinical Pharmacy, Center for Clinical Pharmacy and Sciences, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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