Document Detail


Optimal erythrocyte ribavirin level to reduce the risk of anemia and obtain an early virological response in patients with chronic hepatitis C caused by genotype 1b infection.
MedLine Citation:
PMID:  21151503     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Aims. To determine whether the erythrocyte phosphorylated ribavirin (RBV) level might be a useful index of EVR and risk of anemia and to determine the optimal dose of RBV in 24 patients with hepatitis C with pegylated interferon and RBV. Methodology. The RBV level was measured by a high-performance liquid chromatography. Results and Conclusion. In patients aged 50 years or over, a negative correlation (r = -0.548, P < .05) was observed between the RBV level at week 2 and rate of Hb reduction (ΔHb) at week 4. The ΔHb at week 4 was significantly greater in patients with RBV levels of ≥800 μM (-25.5 ± 10.1%) than in patients with RBV levels <800 μM (-15.6 ± 7.7%). None of the patients with RBV levels <600 μM at week 2 achieved EVR and SVR. Thus the optimal levels of erythrocyte phosphorylated RBV at week 2 of therapy in order to achieve EVR without anemia seemed to be 600-800 μM.
Authors:
Rie Kubota; Takako Komiyama; Naoki Kumagai; Miyuki Kimijima; Keiko Mitsuki; Junko Uetake; Fumihiko Kaneko; Satoshi Tsunematsu; Kanji Tsuchimoto
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Publication Detail:
Type:  Journal Article     Date:  2010-09-08
Journal Detail:
Title:  Hepatitis research and treatment     Volume:  2010     ISSN:  2090-1372     ISO Abbreviation:  Hepat Res Treat     Publication Date:  2010  
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101542600     Medline TA:  Hepat Res Treat     Country:  United States    
Other Details:
Languages:  eng     Pagination:  495928     Citation Subset:  -    
Affiliation:
Pharmacy Practice and Sciences, Department of Clinical Pharmacy, Center for Clinical Pharmacy and Sciences, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
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