Document Detail


Optimal elastomeric scaffold leaflet shape for pulmonary heart valve leaflet replacement.
MedLine Citation:
PMID:  23294966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Surgical replacement of the pulmonary valve (PV) is a common treatment option for congenital pulmonary valve defects. Engineered tissue approaches to develop novel PV replacements are intrinsically complex, and will require methodical approaches for their development. Single leaflet replacement utilizing an ovine model is an attractive approach in that candidate materials can be evaluated under valve level stresses in blood contact without the confounding effects of a particular valve design. In the present study an approach for optimal leaflet shape design based on finite element (FE) simulation of a mechanically anisotropic, elastomeric scaffold for PV replacement is presented. The scaffold was modeled as an orthotropic hyperelastic material using a generalized Fung-type constitutive model. The optimal shape of the fully loaded PV replacement leaflet was systematically determined by minimizing the difference between the deformed shape obtained from FE simulation and an ex-vivo microCT scan of a native ovine PV leaflet. Effects of material anisotropy, dimensional changes of PV root, and fiber orientation on the resulting leaflet deformation were investigated. In-situ validation demonstrated that the approach could guide the design of the leaflet shape for PV replacement surgery.
Authors:
Rong Fan; Ahmed S Bayoumi; Peter Chen; Christopher M Hobson; William R Wagner; John E Mayer; Michael S Sacks
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-05
Journal Detail:
Title:  Journal of biomechanics     Volume:  46     ISSN:  1873-2380     ISO Abbreviation:  J Biomech     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-08     Completed Date:  2013-09-06     Revised Date:  2014-02-25    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  662-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anisotropy
Biomechanical Phenomena
Computer Simulation
Elastomers
Finite Element Analysis
Heart Valve Prosthesis*
Imaging, Three-Dimensional
Models, Animal
Models, Cardiovascular
Prosthesis Design
Pulmonary Valve / anatomy & histology,  radiography,  surgery*
Sheep
Tissue Engineering
Tissue Scaffolds*
X-Ray Microtomography
Grant Support
ID/Acronym/Agency:
HL089750/HL/NHLBI NIH HHS; R01 HL068816/HL/NHLBI NIH HHS; R01 HL089750/HL/NHLBI NIH HHS; R01-HL68816/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Elastomers
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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