Document Detail

Optimal dose of thiamylal in combination with midazolam for induction of anaesthesia.
MedLine Citation:
PMID:  8922769     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The optimal dose range of thiamylal, combined with midazolam, in the induction of anaesthesia was evaluated using haemodynamic variables. METHODS: The 200 patients, aged 30 to 70 yr, were randomly divided into five groups by midazolam dosage. Anaesthesia was induced with midazolam 0.05, 0.075, 0.10, 0.15, or 0.20 Two minutes later, 50 mg thiamylal was administered followed by 25 mg increments until verbal response and eyelash reflex disappeared and blood pressure decreased to a level less than that of preinduction. Tracheal intubation was performed with 0.15 vecuronium. Blood pressure and heart rate were monitored during induction. Optimal induction was defined as a systolic blood pressure one minute after intubation within +/- 20% of that before induction. RESULTS: There were 164 patients whose systolic blood pressure were within these criteria. Blood pressure decreased two minutes after induction and 3 to 15 min after intubation in all groups. Heart rate increased one minute after intubation in 0.05, 0.075 and 0.10 midazolam groups. The optimal range of thiamylal was 4.0 +/- 1.1 (mean + SD), 3.1 +/- 1.2, 2.8 +/- 1.1, 2.3 +/- 1.2, and 1.7 +/- 1.0 in combination with midazolam 0.05, 0.075, 0.10, 0.15, and 0.20, respectively. CONCLUSION: The optimal dose range, to maintain haemodynamic stability, for thiamylal induction of anaesthesia in combination with midazolam, 0.05-0.2 was found to range from 4.0 to 1.7
T Nishiyama; K Hanaoka
Related Documents :
20037149 - Awake light-aided blind nasal intubation: prototype device.
10634839 - Randomised controlled trial of thiopental for intubation in neonates.
9839889 - Pituitary-adrenocortical effects of methoxamine infusion on halothane anaesthetised pon...
18252029 - The use of basic parameters for monitoring the haemodynamic effects of midazolam and ke...
18164579 - Effects of the knee-chest position on cardiac index and propofol requirements during bi...
1259889 - Clearance of indocyanine green as an index of liver function during cyclopropane anaest...
4018039 - Auscultatory measurement of arterial pressure during anaesthesia: a reassessment of kor...
6470309 - Fulminant pulmonary edema after near-drowning: remarkably high colloid osmotic pressure...
8498569 - Subepicardial fiber strain and stress as related to left ventricular pressure and volume.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  43     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-03     Completed Date:  1997-03-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1134-7     Citation Subset:  IM    
Department of Anesthesiology, Faculty of Medicine, University of Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anesthetics, Intravenous / administration & dosage*
Blood Pressure / drug effects
Heart Rate / drug effects
Midazolam / administration & dosage*
Middle Aged
Thiamylal / administration & dosage*
Reg. No./Substance:
0/Anesthetics, Intravenous; 59467-70-8/Midazolam; 77-27-0/Thiamylal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The reversal of profound mivacurium-induced neuromuscular blockade.
Next Document:  Comparison of glucose 7.5% and 0.75% with or without phenylephrine for tetracaine spinal anaesthesia...