Document Detail


Optimal dose of thiamylal in combination with midazolam for induction of anaesthesia.
MedLine Citation:
PMID:  8922769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The optimal dose range of thiamylal, combined with midazolam, in the induction of anaesthesia was evaluated using haemodynamic variables. METHODS: The 200 patients, aged 30 to 70 yr, were randomly divided into five groups by midazolam dosage. Anaesthesia was induced with midazolam 0.05, 0.075, 0.10, 0.15, or 0.20 mg.kg-1. Two minutes later, 50 mg thiamylal was administered followed by 25 mg increments until verbal response and eyelash reflex disappeared and blood pressure decreased to a level less than that of preinduction. Tracheal intubation was performed with 0.15 mg.kg-1 vecuronium. Blood pressure and heart rate were monitored during induction. Optimal induction was defined as a systolic blood pressure one minute after intubation within +/- 20% of that before induction. RESULTS: There were 164 patients whose systolic blood pressure were within these criteria. Blood pressure decreased two minutes after induction and 3 to 15 min after intubation in all groups. Heart rate increased one minute after intubation in 0.05 mg.kg-1, 0.075 mg.kg-1 and 0.10 mg.kg-1 midazolam groups. The optimal range of thiamylal was 4.0 +/- 1.1 (mean + SD), 3.1 +/- 1.2, 2.8 +/- 1.1, 2.3 +/- 1.2, and 1.7 +/- 1.0 mg.kg-1 in combination with midazolam 0.05, 0.075, 0.10, 0.15, and 0.20 mg.kg-1, respectively. CONCLUSION: The optimal dose range, to maintain haemodynamic stability, for thiamylal induction of anaesthesia in combination with midazolam, 0.05-0.2 mg.kg-1 was found to range from 4.0 to 1.7 mg.kg-1.
Authors:
T Nishiyama; K Hanaoka
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  43     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-03     Completed Date:  1997-03-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1134-7     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, Faculty of Medicine, University of Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anesthesia
Anesthetics, Intravenous / administration & dosage*
Blood Pressure / drug effects
Female
Heart Rate / drug effects
Humans
Male
Midazolam / administration & dosage*
Middle Aged
Thiamylal / administration & dosage*
Chemical
Reg. No./Substance:
0/Anesthetics, Intravenous; 59467-70-8/Midazolam; 77-27-0/Thiamylal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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