Document Detail

Optimal dose of preoperative enteral immunonutrition for patients with esophageal cancer.
MedLine Citation:
PMID:  19784723     Owner:  NLM     Status:  MEDLINE    
PURPOSE: A preoperative immunonutrition pharmaceutics diet (IMPACT) significantly reduced the incidence of postoperative infectious complications, but the optimal regimen still remains unclear. We evaluated the optimal dose of a preoperative IMPACT for patients with esophageal carcinoma and the incidence of postoperative complications based on the dose of IMPACT. METHODS: This study design was a prospective nonrandomized study. Twenty patients with thoracic esophageal carcinoma who underwent a right transthoracic subtotal esophagectomy were divided into two groups. These patients were administered immunonutrition of 500 ml/day (IMP500) or 1000 ml/day (IMP1000) for 7 days before the operation. RESULTS: The incidence of postoperative mortality and morbidity was not different between the IMP500 group and the IMP1000 group. No difference was observed in the perioperative changes in inflammatory, immunological and nutritional variables between the two groups. There were no adverse effects in the IMP500 group, but four patients (40%) had diarrhea and four patients (40%) had appetite loss in the IMP1000 group. In the IMP1000 group, only four patients (40%) could take 1000 ml, but others reduced the quantity of IMPACT because of diarrhea and discomfort. CONCLUSION: This study suggests that 500 ml of IMPACT is recommended as an optimal dose for patients with esophageal cancer.
Masaki Nakamura; Makoto Iwahashi; Katsunari Takifuji; Mikihito Nakamori; Teiji Naka; Koichiro Ishida; Toshiyasu Ojima; Takeshi Iida; Masahiro Katsuda; Keiji Hayata; Hiroki Yamaue
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2009-09-27
Journal Detail:
Title:  Surgery today     Volume:  39     ISSN:  1436-2813     ISO Abbreviation:  Surg. Today     Publication Date:  2009  
Date Detail:
Created Date:  2009-09-28     Completed Date:  2010-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  855-60     Citation Subset:  IM    
Second Department of Surgery, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8510, Japan.
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MeSH Terms
8,11,14-Eicosatrienoic Acid / blood
Arachidonic Acid / blood
C-Reactive Protein / analysis
Docosahexaenoic Acids / blood
Dose-Response Relationship, Immunologic
Eicosapentaenoic Acid / blood
Enteral Nutrition / adverse effects,  methods*
Esophageal Neoplasms / immunology,  surgery*
Esophagectomy / adverse effects
Interleukin-6 / blood
Lymphocyte Count
Postoperative Complications* / epidemiology,  immunology,  prevention & control
Preoperative Care*
Prospective Studies
Serum Albumin / analysis
Treatment Outcome
Reg. No./Substance:
0/Interleukin-6; 0/Serum Albumin; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid; 7324-41-6/8,11,14-Eicosatrienoic Acid; 9007-41-4/C-Reactive Protein

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