Document Detail


Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions.
MedLine Citation:
PMID:  22562967     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor synchronization across a population of locally coupled genetic oscillators. An important assumption in these studies is that cells can immediately interact with their new neighbors after arriving at a new location. However, intercellular interactions in cellular systems may need some time to become fully established. How movement affects synchronization in this situation has not been examined. Here, we develop a coupled phase oscillator model in which we consider cell movement and the gradual recovery of intercellular coupling experienced by a cell after movement, characterized by a moving rate and a coupling recovery rate, respectively. We find (1) an optimal moving rate for synchronization and (2) a critical moving rate above which achieving synchronization is not possible. These results indicate that the extent to which movement enhances synchrony is limited by a gradual recovery of coupling. These findings suggest that the ratio of time scales of movement and signaling recovery is critical for information transfer between moving cells.
Authors:
Koichiro Uriu; Saúl Ares; Andrew C Oates; Luis G Morelli
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-04
Journal Detail:
Title:  Physical biology     Volume:  9     ISSN:  1478-3975     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197454     Medline TA:  Phys Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  036006     Citation Subset:  -    
Affiliation:
Theoretical Biology Laboratory, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan. Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany. Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Str. 38, 01187 Dresden, Germany.
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