| Optically patternable polymer films as model interfaces to study cellular behaviour on topographically structured materials. | |
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MedLine Citation:
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PMID: 20566046 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We assessed blood interaction with different micrometer-scale topographies under flow conditions using a micro-fluidic array system. The channels of the micro-fluidic array chip were coated with azobenzene polymer films, which were then topographically structured using a one-step non-contact optical technique. A set of surfaces with different topographies was produced varying laser irradiation duration. These surfaces were then exposed to blood flow. The blood flow rate was measured with a micro-channel array flow analyzer. The measured blood flow rates decreased with time for all the samples, indicating formation of platelet clots which obstruct the channels during flow. This effect appeared enhanced on polymer surfaces having a sinusoidal profile with 200-nm-high ridges and 1.2-μm-grating spacing. The morphology of platelets that adhered on the polymer films was studied by scanning electron microscopy. Platelets adhered on azobenzene surfaces with flat topographies, typically exhibiting filopodia. Platelets adhered on optically structured surfaces also exhibited lamellipodia and appeared flattened on surfaces with the highest ridges. We conclude that surface topography influences blood behaviour on azobenzene polymer films. |
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Authors:
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Caterina Minelli; Akiko Yamamoto; Mi-Jeong Kim |
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Publication Detail:
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Type: Journal Article Date: 2010-06-21 |
Journal Detail:
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Title: Journal of biomaterials science. Polymer edition Volume: 22 ISSN: 1568-5624 ISO Abbreviation: J Biomater Sci Polym Ed Publication Date: 2011 |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007393 Medline TA: J Biomater Sci Polym Ed Country: Netherlands |
Other Details:
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Languages: eng Pagination: 577-88 Citation Subset: IM |
Affiliation:
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International Center for Young Scientists (ICYS), National Institute for Material Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan; Institute of Biomedical Engineering, Imperial College London, Exhibition Road, London SW7 2AZ, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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