Document Detail

Optical tomography of the neonatal brain.
MedLine Citation:
PMID:  17473923     Owner:  NLM     Status:  MEDLINE    
A new method of assessing neurological function and pathology in the newborn infant is being developed based on the transmission of near-infrared light across the brain. Absorption by blood over a range of wavelengths reveals a strong dependency on oxygenation status, and measurements of transmitted light enable the spatial variation in the concentrations of the oxygenated and de-oxygenated forms of hemoglobin to be derived. Optical tomography has so far provided static three-dimensional maps of blood volume and oxygenation as well as dynamic images revealing the brain's response to sensory stimulation and global hemodynamic changes. The imaging modality is being developed as a safe and non-invasive tool that can be utilized at the cotside in intensive care. Optical tomography of the healthy infant brain is also providing a means of studying neurophysiological processes during early development and the potential consequences of prematurity.
Jeremy C Hebden; Topun Austin
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-05-01
Journal Detail:
Title:  European radiology     Volume:  17     ISSN:  0938-7994     ISO Abbreviation:  Eur Radiol     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-11     Completed Date:  2008-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2926-33     Citation Subset:  IM    
Department of Medical Physics & Bioengineering, University College London, Gower Street, London, WC1E 6BT, UK.
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MeSH Terms
Brain / anatomy & histology*,  blood supply*,  pathology*
Carbon Dioxide / metabolism
Cerebral Hemorrhage / diagnosis,  pathology
Cerebrovascular Circulation
Diagnostic Imaging / trends*
Image Interpretation, Computer-Assisted / methods
Imaging, Three-Dimensional / methods*
Infant, Newborn / physiology*
Phantoms, Imaging
Tomography, Optical / methods*
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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