Document Detail

Optical recordings from the human nasal mucosa in response to olfactory stimulation.
MedLine Citation:
PMID:  17709196     Owner:  NLM     Status:  MEDLINE    
Using the intrinsic optical signal the present study aimed to investigate changes in blood flow at the nasal epithelium in response to specific olfactory stimulation. Recording equipment included an endoscope, a CCD camera, and a light source of 617 nm. Two concentrations of the specific olfactory stimulant H(2)S (2.8 and 5.6 ppm), generated by a computer-controlled olfactometer, were used for olfactory stimulation. Eight healthy normosmic volunteers participated. Using 5.6 ppm H(2)S stimuli, responses were typically recorded from the olfactory cleft, middle turbinate, and middle meatus while responses were less pronounced for 2.8 ppm H(2)S stimuli. Response areas were significantly larger for the 5.6 ppm H(2)S stimuli. While further experiments are needed, recordings of the intrinsic optical signal may be used to obtain responses from the nasal cavity to specific olfactory stimuli.
Tadashi Ishimaru; Jens Reden; Franziska Krone; Mandy Scheibe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-08
Journal Detail:
Title:  Neuroscience letters     Volume:  423     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-27     Completed Date:  2007-11-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  231-5     Citation Subset:  IM    
Smell & Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School (Technische Universität Dresden), Fetscherstrasse 74, 01307 Dresden, Germany.
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MeSH Terms
Dose-Response Relationship, Drug
Gamma Cameras
Hydrogen Sulfide / administration & dosage
Image Processing, Computer-Assisted
Middle Aged
Nasal Mucosa / blood supply*
Optics and Photonics
Osmolar Concentration
Photic Stimulation
Regional Blood Flow / physiology
Smell / physiology*
Stimulation, Chemical
Reg. No./Substance:
7783-06-4/Hydrogen Sulfide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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