| Optical and radioisotope indicator dilution measurements in pulmonary edema. | |
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MedLine Citation:
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PMID: 9570225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was a validation of an optical multiple indicator dilution technique for measuring microvascular exchange parameters in edematous lungs by comparison to conventional radioisotope multiple indicator dilution methods. Six anesthetized dogs were studied at baseline and after alloxan infusion to increase capillary permeability. In addition, 11 isolated, perfused dog lungs were studied at baseline and after edema was created by increasing venous pressure or by infusing alloxan to increase vascular permeability. Increased capillary permeability from alloxan infusion led to increases in most but not all capillary exchange parameters as analyzed by mathematical models and measured by both optical and radioisotope methods. Increased vascular pressure led to increased edema but no significant increases in capillary exchange parameters. Two-way analysis of variance (ANOVA; variations in baseline versus pressure or alloxan and variation in optical versus radioisotope for each transport parameter derived from the mathematical models) indicated few significant differences in capillary exchange parameters between optical and radioisotope measures. Newman-Keuls multiple comparison tests did uncover some variations between a few of the group-mean values derived from optical and radioisotope methods. However, optical and radioisotope parameter measurements were highly correlated for all studies regardless of the mathematical model used for analysis. |
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Authors:
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S DeMarino; L E Olson; N A Pou; S U Adams; T R Harris |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of biomedical engineering Volume: 26 ISSN: 0090-6964 ISO Abbreviation: Ann Biomed Eng Publication Date: 1998 May-Jun |
Date Detail:
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Created Date: 1998-07-10 Completed Date: 1998-07-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 417-30 Citation Subset: IM |
Affiliation:
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Johnson and Johnson Medical, Inc., Tampa, FL, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alloxan
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pharmacology Animals Capillary Permeability / drug effects Disease Models, Animal Dogs Microcirculation Propylene Glycol Pulmonary Circulation Pulmonary Edema / physiopathology* Radioisotope Dilution Technique Respiratory Distress Syndrome, Adult / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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HL-07123/HL/NHLBI NIH HHS; HL-39155/HL/NHLBI NIH HHS; RR-06558/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-71-5/Alloxan; 57-55-6/Propylene Glycol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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