| Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects. | |
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MedLine Citation:
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PMID: 20615033 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow (rCBF(DCS)); and oxygen metabolism (rCMRO(2)). Concurrent measurements with arterial spin-labeled magnetic resonance imaging (rCBF(ASL-MRI), n=12) cross-validate rCBF(DCS) against rCBF(ASL-MRI), showing good agreement (R=0.7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population. |
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Authors:
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Turgut Durduran; Chao Zhou; Erin M Buckley; Meeri N Kim; Guoqiang Yu; Regine Choe; J William Gaynor; Thomas L Spray; Suzanne M Durning; Stefanie E Mason; Lisa M Montenegro; Susan C Nicolson; Robert A Zimmerman; Mary E Putt; Jiongjiong Wang; Joel H Greenberg; John A Detre; Arjun G Yodh; Daniel J Licht |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical optics Volume: 15 ISSN: 1560-2281 ISO Abbreviation: J Biomed Opt Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-07-09 Completed Date: 2010-10-29 Revised Date: 2011-12-16 |
Medline Journal Info:
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Nlm Unique ID: 9605853 Medline TA: J Biomed Opt Country: United States |
Other Details:
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Languages: eng Pagination: 037004 Citation Subset: IM |
Affiliation:
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ICFO-Institut de Ciencies Fotoniques, Av Canal Olimpic s/n, Castelldefels 08860, Spain. durduran@alumni.upenn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carbon Dioxide
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metabolism Cerebral Cortex / blood supply* Heart Defects, Congenital / blood*, physiopathology* Hemodynamics / physiology Hemoglobins / metabolism Humans Hypercapnia / physiopathology* Infant, Newborn Magnetic Resonance Imaging Optics and Photonics / methods* Oxyhemoglobins / metabolism Regional Blood Flow / physiology Spectroscopy, Near-Infrared / methods* Spectrum Analysis / methods |
| Grant Support | |
ID/Acronym/Agency:
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EB-007610/EB/NIBIB NIH HHS; HD-26979/HD/NICHD NIH HHS; HL-077699/HL/NHLBI NIH HHS; HL-57835/HL/NHLBI NIH HHS; NR 0016/NR/NINR NIH HHS; NS-45839/NS/NINDS NIH HHS; NS-52380/NS/NINDS NIH HHS; NS-60653/NS/NINDS NIH HHS; P41 RR002305-236856/RR/NCRR NIH HHS; R01 MH080892-01A2/MH/NIMH NIH HHS; R01 MH080892-03/MH/NIMH NIH HHS; R01 MH080892-04/MH/NIMH NIH HHS; RR-02305/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Oxyhemoglobins; 124-38-9/Carbon Dioxide; 9008-02-0/deoxyhemoglobin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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