Document Detail

Optical imaging of low Mg(2+)-induced spontaneous epileptiform activity in combined rat entorhinal cortex-hippocampal slices.
MedLine Citation:
PMID:  9223065     Owner:  NLM     Status:  MEDLINE    
A reproducible increase in transmission of infrared light was observed during spontaneous seizure-like events (SLEs) induced by low Mg2+ solutions in combined rat entorhinal cortex-hippocampal slices. Comparison of half maxima of transmission change in different regions indicated propagation of SLEs from the medial entorhinal cortex towards the temporal cortex suggesting spread along existing anatomical pathways. Thus, optical imaging of spontaneous epileptiform activity is possible and may improve the assessment of spread patterns. The optical signal outlasted both SLEs and associated K+ signals. In contrast, the tetraethylammonium signal, indicating changes of the extracellular space (ECS) volume, had a longer time course than the transmission changes. ECS volume changes are widely held to be responsible for transmission change. Our data suggest that other mechanisms may also contribute to increased light transmission during epileptiform activity.
H Meierkord; S Schuchmann; K Buchheim; U Heinemann
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  8     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-08-29     Completed Date:  1997-08-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1857-61     Citation Subset:  IM    
Neurologische Klinik und Poliklinik, Universitätsklinikum Charité, Humboldt-Universität Berlin, Germany.
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MeSH Terms
Entorhinal Cortex / pathology*
Epilepsy / pathology*
Extracellular Space / physiology
Image Cytometry
Image Processing, Computer-Assisted
Infrared Rays
Magnesium Deficiency / pathology*
Potassium / physiology
Rats, Wistar
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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