Document Detail

Optical imaging for brain tissue characterization using relative fluorescence lifetime imaging.
MedLine Citation:
PMID:  23760460     Owner:  NLM     Status:  MEDLINE    
An autofluorescence lifetime wide-field imaging system that can generate contrast in underlying tissue structures of normal and malignant brain tissue samples with video rate acquisition and processing time is presented. Images of the investigated tissues were acquired with high resolution (∼35 μm) using an algorithm to produce contrast based on differences in relative lifetimes. Sufficient contrast for delineation was produced without the computation of fluorescence decay times or Laguerre coefficients. The imaged tissues were sent for histological analysis that confirmed the detected imaged tissues morphological findings and correlations between relative lifetime maps and histology identified.
Asael Papour; Zach Taylor; Adria Sherman; Desiree Sanchez; Gregory Lucey; Linda Liau; Oscar Stafsudd; William Yong; Warren Grundfest
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  18     ISSN:  1560-2281     ISO Abbreviation:  J Biomed Opt     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-13     Completed Date:  2013-12-31     Revised Date:  2014-07-07    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  60504     Citation Subset:  IM    
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MeSH Terms
Brain / pathology*
Brain Neoplasms / diagnosis,  pathology*
Equipment Design
Glioma / diagnosis,  pathology*
Image Processing, Computer-Assisted
Microscopy, Fluorescence / methods*
Microscopy, Video / instrumentation*,  methods*
Specimen Handling
Tomography, Optical Coherence

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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