| Optical controlling reveals time-dependent roles for adult-born dentate granule cells. | |
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MedLine Citation:
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PMID: 23143513 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Accumulating evidence suggests that global depletion of adult hippocampal neurogenesis influences its function and that the timing of the depletion affects the deficits. However, the behavioral roles of adult-born neurons during their establishment of projections to CA3 pyramidal neurons remain largely unknown. We used a combination of retroviral and optogenetic approaches to birth date and reversibly control a group of adult-born neurons in adult mice. Adult-born neurons formed functional synapses on CA3 pyramidal neurons as early as 2 weeks after birth, and this projection to the CA3 area became stable by 4 weeks in age. Newborn neurons at this age were more plastic than neurons at other stages. Notably, we found that reversibly silencing this cohort of ~4-week-old cells after training, but not cells of other ages, substantially disrupted retrieval of hippocampal memory. Our results identify a restricted time window for adult-born neurons essential in hippocampal memory retrieval. |
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Authors:
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Yan Gu; Maithe Arruda-Carvalho; Jia Wang; Stephen R Janoschka; Sheena A Josselyn; Paul W Frankland; Shaoyu Ge |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-11-11 |
Journal Detail:
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Title: Nature neuroscience Volume: 15 ISSN: 1546-1726 ISO Abbreviation: Nat. Neurosci. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-28 Completed Date: 2013-01-29 Revised Date: 2013-05-13 |
Medline Journal Info:
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Nlm Unique ID: 9809671 Medline TA: Nat Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 1700-6 Citation Subset: IM |
Affiliation:
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Department of Neurobiology and Behavior, SUNY at Stony Brook, Stony Brook, New York, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Conditioning, Operant / physiology Dentate Gyrus / cytology*, growth & development* Female Maze Learning / physiology Mice Mice, Inbred C57BL Neurogenesis / physiology* Neuronal Plasticity / physiology* Pyramidal Cells / growth & development* Random Allocation Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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MOP74650//Canadian Institutes of Health Research; MOP86762//Canadian Institutes of Health Research; NS065915/NS/NINDS NIH HHS; R01 NS065915/NS/NINDS NIH HHS |
| Comments/Corrections | |
Comment In:
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Nat Neurosci. 2012 Dec;15(12):1611-2
[PMID:
23187692
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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