Document Detail


Optical coherent tomography for in vivo determination of changes in hair cross section and diameter during treatment with glucocorticosteroids--a simple method to screen for doping substances?
MedLine Citation:
PMID:  18797173     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eighty percent of hair follicles are in the growing phase. They grow approximately 0.3 mm/day. The hair follicles are surrounded by a close network of capillaries, which supplies them with nutrients. It is well known that substances which influence the metabolic processes of humans also influence hair growth. Steroids, which are used for doping in sport, are among these substances. In the present paper, optical coherent tomography is used for the analysis of changes in the hair structure during the application of steroids for the treatment of patients suffering from auto-immune diseases. Significant differences in the hair cross section could be detected during treatment, while the shape of the hairs was not influenced. It could be demonstrated that optical coherence tomography is a suitable, non-invasive and low-cost measuring technique that can be applied for doping control and screening. As a result of this screening process, only those athletes who show abnormalities in hair parameters would need to be investigated by classical analytical methods. The results presented in this study are not only important for doping controls, but also for several clinical applications, such as therapy and compliance control in cases where the applied substances induce changes in the hair structure.
Authors:
J Lademann; J Shevtsova; A Patzelt; H Richter; N D Gladkowa; V M Gelikonov; S A Gonchukov; W Sterry; A M Sergeev; U Blume-Peytavi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-17
Journal Detail:
Title:  Skin pharmacology and physiology     Volume:  21     ISSN:  1660-5535     ISO Abbreviation:  Skin Pharmacol Physiol     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-27     Completed Date:  2009-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101188418     Medline TA:  Skin Pharmacol Physiol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  312-7     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Affiliation:
Center of Applied Cutaneous Physiology, Charité Universitatsmedizin Berlin, Berlin, Germany. juergen.lademann@charite.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Autoimmune Diseases / drug therapy
Doping in Sports
Glucocorticoids / analysis*,  pharmacokinetics
Hair / chemistry
Humans
Middle Aged
Substance Abuse Detection / methods*
Tomography, Optical Coherence / methods*
Chemical
Reg. No./Substance:
0/Glucocorticoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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