Document Detail


Optical coherence tomography of the newborn airway.
MedLine Citation:
PMID:  18564528     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Acquired subglottic stenosis in a newborn is often associated with prolonged endotracheal intubation. This condition is generally diagnosed during operative endoscopy after airway injury has occurred. Unfortunately, endoscopy is unable to characterize the submucosal changes observed in such airway injuries. Other modalities, such as magnetic resonance imaging, computed tomography, and ultrasound, do not possess the necessary level of resolution to differentiate scar, neocartilage, and edema. Optical coherence tomography (OCT) is an imaging modality that produces high-resolution, cross-sectional images of living tissue (8 to 20 microm). We examined the ability of this noninvasive technique to characterize the newborn airway in a prospective clinical trial.
METHODS: Twelve newborn patients who required ventilatory support underwent OCT airway imaging. Comparative analysis of intubated and non-intubated states was performed.
RESULTS: Imaging of the supraglottis, glottis, subglottis, and trachea was performed in 12 patients, revealing unique tissue characteristics as related to turbidity, signal backscattering, and architecture. Multiple structures were identified, including the vocal folds, cricoid cartilage, tracheal rings, ducts, glands, and vessels.
CONCLUSIONS: Optical coherence tomography clearly identifies in vivo tissue layers and regional architecture while offering detailed information concerning tissue microstructures. The diagnostic potential of this technology makes OCT a promising modality in the study and surveillance of the neonatal airway.
Authors:
James M Ridgway; Jianping Su; Ryan Wright; Shuguang Guo; David C Kim; Roberto Barretto; Gurpreet Ahuja; Ali Sepehr; Jorge Perez; Jack H Sills; Zhongping Chen; Brian J F Wong
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Annals of otology, rhinology, and laryngology     Volume:  117     ISSN:  0003-4894     ISO Abbreviation:  Ann. Otol. Rhinol. Laryngol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-06-20     Completed Date:  2008-07-01     Revised Date:  2011-05-30    
Medline Journal Info:
Nlm Unique ID:  0407300     Medline TA:  Ann Otol Rhinol Laryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  327-34     Citation Subset:  AIM; IM    
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, University of California-Irvine, Irvine, California, USA.
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MeSH Terms
Descriptor/Qualifier:
Diagnosis, Differential
Equipment Design
Follow-Up Studies
Gestational Age
Humans
Infant, Newborn
Laryngoscopy / methods
Laryngostenosis / diagnosis*
Larynx / pathology*
Reproducibility of Results
Tomography, Optical Coherence / instrumentation*
Grant Support
ID/Acronym/Agency:
CA 91717/CA/NCI NIH HHS; DC 006026/DC/NIDCD NIH HHS; EB 00293/EB/NIBIB NIH HHS; M01-RR00827-28/RR/NCRR NIH HHS; R01 CA091717-05/CA/NCI NIH HHS; R01 EB000293-07/EB/NIBIB NIH HHS; RR 01192/RR/NCRR NIH HHS
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