Document Detail

Optical coherence tomography measurement of nerve fiber layer thickness and the likelihood of a visual field defect.
MedLine Citation:
PMID:  12383810     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine if optical coherence tomography (OCT) measurements of nerve fiber layer (NFL) thickness can be used to predict the presence of visual field defects (VFD) associated with glaucoma.
DESIGN: Quota-sampled, cross-sectional study.
METHODS: Retrospective study of OCT NFL thickness measurements in 276 eyes of 276 subjects. All persons received OCT NFL thickness analysis; 136 eyes underwent frequency-doubling technology (FDT) perimetry; and 140 eyes underwent Swedish interactive threshold algorithm (SITA) perimetry. We defined a parameter called NFL(50), which is the NFL thickness value at which there was a 50% likelihood of a VFD with either SITA or FDT perimetry. We evaluated the use of NFL(50).
RESULTS: The mean NFL thickness with (n = 68) and without (n = 68) a VFD in the FDT group was 93.2 microm +/- 22.6 and 108.4 microm +/- 14.1, respectively. The mean NFL thickness with (n = 70) and without (n = 70) a VFD in the SITA group was 78.9 microm +/- 24.8 and 103.0 microm +/- 18.0, respectively. The FDT mean NFL(50) value was 98.5 microm. The SITA mean NFL(50) value was 87.0 microm. The area under the receiver operator characteristic (AROC) curve for mean NFL was 0.73, and the positive predictive value (PPV) for FDT mean NFL(50) was 72.2%. For SITA mean NFL, the AROC was 0.79 and the PPV for NFL(50) was 77.2%.
CONCLUSION: Nerve fiber layer thickness analysis using OCT may be clinically useful in identifying subjects who have visual field loss. However, the PPV suggests that OCT may need higher resolution and better reproducibility to enhance its sensitivity and specificity for population screening.
Zinaria Y Williams; Joel S Schuman; Lisa Gamell; Ajit Nemi; Ellen Hertzmark; James G Fujimoto; Cynthia Mattox; Julie Simpson; Gadi Wollstein
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  134     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-17     Completed Date:  2002-11-06     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  538-46     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cross-Sectional Studies
Diagnostic Techniques, Ophthalmological*
Differential Threshold
Glaucoma / complications*
Likelihood Functions
Middle Aged
Nerve Fibers / pathology*
Optics and Photonics
Reference Values
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Vision Disorders / diagnosis*,  etiology*
Visual Field Tests / methods
Visual Fields*
Grant Support
P30 EY013078-01A1/EY/NEI NIH HHS; P30-EY13078/EY/NEI NIH HHS; R01 EY011289/EY/NEI NIH HHS; R01 EY011289-15/EY/NEI NIH HHS; R01 EY013178/EY/NEI NIH HHS; R01 EY013178-01/EY/NEI NIH HHS; R01-EY11289/EY/NEI NIH HHS; R01-EY13178/EY/NEI NIH HHS
Comment In:
Am J Ophthalmol. 2003 May;135(5):744; author reply 744-5   [PMID:  12719100 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Performance of glaucoma mass screening with only a visual field test using frequency-doubling techno...
Next Document:  Anisometropia and degree of optic nerve damage in chronic open-angle glaucoma.