Document Detail

Optical coherence tomography in patients with acute coronary syndrome.
MedLine Citation:
PMID:  20542823     Owner:  NLM     Status:  MEDLINE    
Optical coherence tomography (OCT) is a novel invasive imaging technology that allows in vivo assessment of the coronary wall with high resolution (approximately 15 micron). OCT offers a number of specific diagnostic features to study culprit lesions in patients suffering from acute coronary syndrome (ACS). Clinical OCT studies in patients presenting with ACS were able to confirm post mortem histopathology findings and shed light on the dynamic nature of atherosclerotic plaque formation, modification and rupture. OCT confirmed in vivo that the incidence of target lesion and remote TCFA varies with the clinical syndrome of the patients, being most pronounced in patients with acute myocardial infarction as compared to patients with stable angina. In culprit lesions where rupture of a fibrous cap has been documented, the fibrous cap thickness was in the range of 50 micron and macrophage density was elevated. Encouraging small scale clinical studies evaluated treatment effects in this population. OCT was used to demonstrate statin effects on fibrous cap thickness or the effects of different stent designs. The markedly improved image quality and user-friendliness of the second generation, Fourier-domain OCT, will allow large scale clinical application and thus, will increase our understanding of the pathophysiology and the prevention of ACS.
Evelyn Regar; Gijs van Soest; Nico Bruining; Alina A Constantinescu; Robert J van Geuns; Wim van der Giessen; Patrick W Serruys
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology     Volume:  6 Suppl G     ISSN:  1969-6213     ISO Abbreviation:  EuroIntervention     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101251040     Medline TA:  EuroIntervention     Country:  France    
Other Details:
Languages:  eng     Pagination:  G154-60     Citation Subset:  IM    
Thoraxcenter, Department of Interventional Cardiology, Erasmus MC, Rotterdam, The Netherlands.
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MeSH Terms
Acute Coronary Syndrome / complications,  diagnosis*,  therapy
Angina Pectoris / etiology
Angioplasty, Transluminal, Percutaneous Coronary
Coronary Angiography
Coronary Vessels / pathology*
Fourier Analysis
Image Interpretation, Computer-Assisted
Myocardial Infarction / etiology
Predictive Value of Tests
Tomography, Optical Coherence*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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