Document Detail


Optical coherence tomography as a tool for measuring morphogenetic deformation of the looping heart.
MedLine Citation:
PMID:  17721979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Optical coherence tomography (OCT) was used to investigate morphogenesis of the embryonic chick heart during the first phase of looping (c-looping), as the heart bends and twists into a c-shaped tube. The present study focuses on the morphomechanical effects of the splanchnopleure (SPL), a membrane that has been shown to play a major role in cardiac torsion by pressing against the ventral surface of the heart. Without the SPL, rightward torsion (rotation) is delayed. The images show that compressive forces exerted by the SPL alter the shapes of the heart tube and primitive atria, as well as their spatial relationships. The SPL normally holds the heart in the plane of the embryo and forces cardiac jelly (CJ) out of adjacent regions in the atria. When the SPL is removed, cross-sections become more circular, CJ is more uniformly distributed, and the heart displaces ventrally. In addition, OCT-based morphogenetic strain maps were measured during looping by tracking the three-dimensional motions of microspheres placed on the myocardium. The spatial-temporal patterns of the strains correlated well with the observed behavior of the heart, including delayed torsion that occurs in SPL-lacking embryos. These results illustrate the potential of OCT as a tool in studies of morphogenesis, as well as provide a better understanding of the mechanical forces that drive cardiac looping.
Authors:
Benjamen A Filas; Igor R Efimov; Larry A Taber
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Anatomical record (Hoboken, N.J. : 2007)     Volume:  290     ISSN:  1932-8486     ISO Abbreviation:  Anat Rec (Hoboken)     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-30     Completed Date:  2007-09-27     Revised Date:  2009-12-16    
Medline Journal Info:
Nlm Unique ID:  101292775     Medline TA:  Anat Rec (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1057-68     Citation Subset:  IM    
Copyright Information:
Copyright 2007 Wiley-Liss, Inc.
Affiliation:
Department of Biomedical Engineering, Washington University, St. Louis, Missouri 63130, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chick Embryo
Chickens
Heart / embryology*,  physiology
Heart Atria / embryology
Imaging, Three-Dimensional*
Mesenteric Veins / embryology
Models, Biological
Myocardial Contraction
Organogenesis
Reproducibility of Results
Research Design
Rotation
Stress, Mechanical
Time Factors
Tomography, Optical Coherence*
Grant Support
ID/Acronym/Agency:
R01 GM075200/GM/NIGMS NIH HHS; R01 HL083393/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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