Document Detail

Optical coherence tomography as a tool for measuring morphogenetic deformation of the looping heart.
MedLine Citation:
PMID:  17721979     Owner:  NLM     Status:  MEDLINE    
Optical coherence tomography (OCT) was used to investigate morphogenesis of the embryonic chick heart during the first phase of looping (c-looping), as the heart bends and twists into a c-shaped tube. The present study focuses on the morphomechanical effects of the splanchnopleure (SPL), a membrane that has been shown to play a major role in cardiac torsion by pressing against the ventral surface of the heart. Without the SPL, rightward torsion (rotation) is delayed. The images show that compressive forces exerted by the SPL alter the shapes of the heart tube and primitive atria, as well as their spatial relationships. The SPL normally holds the heart in the plane of the embryo and forces cardiac jelly (CJ) out of adjacent regions in the atria. When the SPL is removed, cross-sections become more circular, CJ is more uniformly distributed, and the heart displaces ventrally. In addition, OCT-based morphogenetic strain maps were measured during looping by tracking the three-dimensional motions of microspheres placed on the myocardium. The spatial-temporal patterns of the strains correlated well with the observed behavior of the heart, including delayed torsion that occurs in SPL-lacking embryos. These results illustrate the potential of OCT as a tool in studies of morphogenesis, as well as provide a better understanding of the mechanical forces that drive cardiac looping.
Benjamen A Filas; Igor R Efimov; Larry A Taber
Related Documents :
24423149 - Effects of saxagliptin on early microvascular changes in patients with type 2 diabetes.
23763159 - A photostable bi-luminophore pressure-sensitive paint measurement system developed with...
1215639 - Oxidative phosphorylation in mitochondria isolated from stressed rat heart.
21780019 - Primary suture-less closure of gastroschisis using negative pressure dressing (wound va...
18045349 - Third degree atrioventricular block and accelerated idioventricular rhythm associated w...
23922999 - Relationship between the magnitude of intraocular pressure during an episode of acute e...
16083509 - Complications after cryosurgery with new miniature cryoprobes in long hollow bones: an ...
2140019 - Ventricular hypertrophy and presynaptic regulation of sympathetic function.
669589 - Pulmonary histological appearances in fatal paraquat poisoning.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Anatomical record (Hoboken, N.J. : 2007)     Volume:  290     ISSN:  1932-8486     ISO Abbreviation:  Anat Rec (Hoboken)     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-30     Completed Date:  2007-09-27     Revised Date:  2009-12-16    
Medline Journal Info:
Nlm Unique ID:  101292775     Medline TA:  Anat Rec (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1057-68     Citation Subset:  IM    
Copyright Information:
Copyright 2007 Wiley-Liss, Inc.
Department of Biomedical Engineering, Washington University, St. Louis, Missouri 63130, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chick Embryo
Heart / embryology*,  physiology
Heart Atria / embryology
Imaging, Three-Dimensional*
Mesenteric Veins / embryology
Models, Biological
Myocardial Contraction
Reproducibility of Results
Research Design
Stress, Mechanical
Time Factors
Tomography, Optical Coherence*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Oxidant-induced atrogin-1 and transforming growth factor-beta1 precede alcohol-related myopathy in r...
Next Document:  Techniques for modeling muscle-induced forces in finite element models of skeletal structures.