Document Detail

Optical coherence tomography: advanced technology for the endoscopic imaging of Barrett's esophagus.
MedLine Citation:
PMID:  11147939     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND STUDY AIMS: Endoscopic optical coherence tomography (OCT) is an emerging medical technology capable of generating high-resolution cross-sectional imaging of tissue microstructure in situ and in real time. We assess the use and feasibility of OCT for real-time screening and diagnosis of Barrett's esophagus, and also review state-of-the-art OCT technology for endoscopic imaging. MATERIALS AND METHODS: OCT imaging was performed as an adjunct to endoscopic imaging of the human esophagus. Real-time OCT (13-microm resolution) was used to perform image-guided evaluation of normal esophagus and Barrett's esophagus. Beam delivery was accomplished with a 1-mm diameter OCT catheter-probe that can be introduced into the accessory channel of a standard endoscope. Different catheter-probe imaging designs which performed linear and radial scanning were assessed. Novel ultrahigh-resolution (1.1-microm resolution) and spectroscopic OCT techniques were used to image in vitro specimens of Barrett's esophagus. RESULTS: Endoscopic OCT images revealed distinct layers of normal human esophagus extending from the epithelium to the muscularis propria. In contrast, the presence of gland- and crypt-like morphologies and the absence of layered structures were observed in Barrett's esophagus. All OCT images showed strong correlations with architectural morphology in histological findings. Ultrahigh-resolution OCT techniques achieved 1.1-microm image resolution in in vitro specimens and showed enhanced resolution of architectural features. Spectroscopic OCT identified localized regions of wavelength-dependent optical scattering, enhancing the differentiation of Barrett's esophagus. CONCLUSIONS: OCT technology with compact fiberoptic imaging probes can be used as an adjunct to endoscopy for real-time image-guided evaluation of Barrett's esophagus. Linear and radial scan patterns have different advantages and limitations depending upon the application. Ultrahigh-resolution and spectroscopic OCT techniques improve structural tissue recognition and suggest future potential for resolution and contrast enhancements in clinical studies. A new balloon catheter-probe delivery device is proposed for systematic imaging and screening of the esophagus.
X D Li; S A Boppart; J Van Dam; H Mashimo; M Mutinga; W Drexler; M Klein; C Pitris; M L Krinsky; M E Brezinski; J G Fujimoto
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endoscopy     Volume:  32     ISSN:  0013-726X     ISO Abbreviation:  Endoscopy     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-05     Completed Date:  2001-04-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0215166     Medline TA:  Endoscopy     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  921-30     Citation Subset:  IM    
Dept. of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, USA.
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MeSH Terms
Barrett Esophagus / pathology*
Equipment Design
Esophagoscopy / methods*
Feasibility Studies
Grant Support
9-RO1-CA75289-03/CA/NCI NIH HHS; 9-RO1-EY11289-14/EY/NEI NIH HHS; R01-AR44812-02/AR/NIAMS NIH HHS

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