Document Detail


Optical coherence tomography measurements of retinal nerve fiber layer thickness in chinese children and teenagers.
MedLine Citation:
PMID:  21048509     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PURPOSE: To establish a reference range of retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (OCT) in Chinese children and teenagers, and to investigate its relationship with sex, age, eye side, and refractive error.
METHODS: A total of 398 eyes from 199 normal Chinese aged 5 to 18 years (a mean of 10.4±2.7 y), who were undergoing physical examination in the Department of Ophthalmology, were recruited for this study. Their RNFL thicknesses were measured by OCT [OCT, Stratus OCT (OCT3); Carl Zeiss Meditec, Dublin, Calif], and 7 parameters associated with the RNFL thickness were analyzed by the RNFL thickness average analysis program. The influences of several factors (such as sex, age, eye side, and refractive error) on RNFL thickness were also analyzed.
RESULTS: We found that the global average RNFL thickness (±SD) was 112.36±9.21 μm in the present cohort. The thickest RNFL was located at the superior (148.73±17.06 μm) and inferior (142.08±16.03 μm) quadrants of the retina, followed by the temporal (83.82±13.53 μm) quadrant and the nasal (74.84±15.03 μm) quadrant. There was no significant difference in the measurements between boys and girls, however, the eye side had significant influence on RNFL thickness (P<0.01). We also found that the average RNFL thickness was positively correlated with the age and refractive error (P<0.01).
CONCLUSIONS: This study has established a standard reference of RNFL thickness measurements in Chinese aged 5 to 18 years by OCT, which may help to identify the changes of RNFL thickness in children and teenagers in Chinese and other parts of East Asia countries.
Authors:
Jin Qian; Weijun Wang; Xian Zhang; Fenghua Wang; Yuan Jiang; Wenqiu Wang; Shan Xu; Ying Wu; Yi Su; Xun Xu; Xiaodong Sun
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of glaucoma     Volume:  20     ISSN:  1536-481X     ISO Abbreviation:  J. Glaucoma     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9300903     Medline TA:  J Glaucoma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  509-13     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Shanghai Eye Research Institute, First People's Hospital of Shanghai, Shanghai Jiaotong University, Shanghai, PR China.
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