Document Detail

Optic tectum morphogenesis: A step-by-step model based on the temporal-spatial organization of the cell proliferation. Significance of deterministic and stochastic components subsumed in the spatial organization.
MedLine Citation:
PMID:  22473829     Owner:  NLM     Status:  Publisher    
BACKGROUND: Cell proliferation plays an important morphogenetic role. This work analyzes the temporal-spatial organization of cell proliferation as an attempt to understand its contribution to the chick optic tectum (OT) morphogenesis. RESULTS: A morphogenetic model based on space-dependent differences in cell proliferation is presented. Step1: a medial Zone of High Mitotic Density (mZHMD) appears at the caudal zone.Step2: the mZHMD expands cephalically forming the dorsal curvature and then duplicates into two bilateral ZHMDs (bZHMD).Step3: the bZHMDs move toward the central region of each hemitectum.Step4: the planar expansion of both bZHMD and a relative decrement in the dorsal midline growth produces a dorsal medial groove separating the tectal hemispheres.Step5: a relative caudal displacement of the bZHMDs produces the OT caudal curvature. Numerical sequences derived from records of mitotic cells spatial co-ordinates, analyzed as stochastic point processes, show that they correspond to 1/f((β)) processes. The spatial organization subsumes deterministic and stochastic components. CONCLUSIONS: The deterministic component describes the presence of a long-range influence that installs an asymmetric distribution of cell proliferation. i.e, an asymmetrically located ZHMD that print space-dependent differences onto the tectal corticogenesis. The stochastic component reveals short-range anti-correlations reflecting spatial clusterization and synchronization between neighboring cells. Developmental Dynamics, 2012. © 2012 Wiley Periodicals, Inc.
Melina Rapacioli; Santiago Duarte; Alejandra Rodríguez Celín; Luciano Fiore; Luisa Teruel; Gabriel Scicolone; Viviana Sánchez; Vladimir Flores
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-3
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  -     ISSN:  1097-0177     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Interdisciplinary Group in Theoretical Biology, Department of Biostructural Sciences, Favaloro University, Solís 453 (C1078AAI) Buenos Aires, Argentina.
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