| Optic pathway gliomas. | |
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MedLine Citation:
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PMID: 21857190 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: : Childhood optic pathway gliomas (OPGs) are low-grade neoplasms intrinsic to the optic nerve, optic chiasm, tracts, and radiations. The management of OPGs is still a highly controversial topic among neuro-ophthalmologists. EVIDENCE ACQUISITION: : Authors' personal experience and literature review. RESULTS: : This review describes our current understanding of the behavior of OPGs and discusses advances in their imaging, evaluation, and management. Patients with OPGs that progress are typically treated with chemotherapy using carboplatin and vincristine; however, newer approaches to therapy are being explored. CONCLUSIONS: : Although chemotherapy is the mainstay of treatment when indicated, multicenter collaborative studies involving oncologists and neuro-ophthalmologists, both retrospective and prospective, are still needed to establish evidence-based guidelines for the management of children with OPGs. |
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Authors:
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Robert A Avery; Michael J Fisher; Grant T Liu |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society Volume: 31 ISSN: 1536-5166 ISO Abbreviation: J Neuroophthalmol Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431308 Medline TA: J Neuroophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 269-78 Citation Subset: IM |
Affiliation:
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Department of Neurology (RAA) and Gilbert Family Neurofibromatosis Institute (RAA), Children's National Medical Center, Washington, District of Columbia; Division of Oncology (MJF) and Neuro-Ophthalmology Service (GTL), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; and Departments of Pediatrics (MJF), Neurology (GTL), and Ophthalmology (GTL), School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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