| Optic nerve tumor in tuberous sclerosis complex is not responsive to sirolimus. | |
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MedLine Citation:
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PMID: 20472200 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 12-year-old girl with clinically established tuberous sclerosis complex, and without signs of neurofibromatosis type 1, developed a right retro-ocular optic nerve tumor. After rapid growth for 1 year after its discovery, the optic nerve tumor demonstrated modest progression. The patient received the mammalian target of rapamycin inhibitor, sirolimus, for recurrent subependymal giant cell brain tumors. Although her left ventricular subependymal giant cell tumor demonstrated a 49% reduction in volume, the optic nerve tumor did not respond, and even underwent slight (6%) growth during the 16-month treatment. The quality of this child's vision has remained normal in both eyes, and she is otherwise asymptomatic with regard to the optic nerve tumor. |
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Authors:
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Steven P Sparagana; David C Wilkes; Catherine E Thompson; Daniel C Bowers |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric neurology Volume: 42 ISSN: 1873-5150 ISO Abbreviation: Pediatr. Neurol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-17 Completed Date: 2010-08-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 443-6 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Neurology, Texas Scottish Rite Hospital for Children, 2222 Welborn Street, Dallas, TX 75219, USA. steven.sparagana@tsrh.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibiotics, Antineoplastic
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therapeutic use Astrocytoma / drug therapy*, pathology Brain Neoplasms / drug therapy*, pathology Child Female Humans Neoplasm Recurrence, Local / drug therapy*, pathology Optic Nerve Neoplasms / drug therapy*, etiology, pathology Sirolimus / therapeutic use* Treatment Outcome Tuberous Sclerosis / complications*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 53123-88-9/Sirolimus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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