Document Detail

Optic nerve sheath diameter in normal-tension glaucoma patients.
MedLine Citation:
PMID:  21398413     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To report on the optic nerve sheath diameter (ONSD) in patients with normal-tension glaucoma (NTG) compared with controls without known optic nerve (ON) or intracranial disease.
METHODS: In 18 patients with NTG (mean age 64.9 ± 8.9 years; 7 women and 11 men), CT of the orbit was performed. 17 age- and gender-matched patients without ON or intracranial disease, who underwent CT of the orbits for non-ophthalmological reasons, served as controls. The widest intraorbital ONSD in axial sections was measured using a standardised technique.
STUDY DESIGN: unmasked. Statistical analysis was performed using an independent two-tailed t Test and the non-parametric Spearman correlation test.
RESULTS: ONSD was significantly (p<0.001) increased in NTG patients (right side: mean 7.9 ± 0.9 mm SD; left: 8.0 ± 1.1 mm) compared with controls (right: 6.3 ± 0.5 mm; left: 6.1 ± 0.6 mm). Neither the NTG nor the control group had a significant difference in ONSD between males and females or between right and left sides.
CONCLUSIONS: An increased ONSD is generally associated with increased intracranial pressure; however, ONSDs in a group of NTG patients also were significantly increased compared with controls. ON sheath compartmentation and thinning of the ON sheath are two possible explanations for an increase in the ONSD in patients with NTG.
Gregor Peter Jaggi; Neil Richard Miller; Josef Flammer; Robert N Weinreb; Luca Remonda; Hanspeter Esriel Killer
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article     Date:  2011-03-11
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  96     ISSN:  1468-2079     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-13     Completed Date:  2012-01-31     Revised Date:  2012-09-24    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  53-6     Citation Subset:  IM    
Department of Ophthalmology, Kantonsspital Aarau, Switzerland.
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MeSH Terms
Aged, 80 and over
Glaucoma, Open-Angle / pathology,  radiography
Intracranial Pressure
Low Tension Glaucoma / pathology,  radiography*
Middle Aged
Myelin Sheath / pathology,  radiography*
Optic Disk / pathology,  radiography*
Optic Nerve / pathology,  radiography*
Orbit / radiography
Tomography, X-Ray Computed / methods*
Comment In:
Br J Ophthalmol. 2012 Aug;96(8):1145-6; author reply 1146   [PMID:  22535329 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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