| Optic nerve projections in patients with primary ciliary dyskinesia. | |
| | |
MedLine Citation:
|
PMID: 21508109 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Purpose: Recently it has been suggested that misprojections of the temporal retina to the contralateral hemisphere might not be specific for patients with albinism and might also be associated with the Kartagener syndrome, i.e., with situs inversus totalis in the presence of primary ciliary dyskinesia (PCD). We tested whether such projection abnormalities are associated with PCD and situs inversus. Methods: In ten patients with PCD (five with situs inversus totalis) and in ten age- and sex-matched controls visual evoked potentials (VEPs) were recorded monocularly: (a) Conventional pattern-onset VEPs (cVEPs) and (b) multifocal VEPs (mfVEPs) for 60 locations comprising a visual field of 44° diameter (VERIS 5.01; EDI). cVEPs from thirteen albinotic subjects were included as reference. For each eye, interhemispheric difference potentials were calculated and correlated with each other to assess the lateralisation of the responses: positive and negative correlation coefficients indicate lateralisations on same or opposite hemispheres, respectively. Misrouted optic nerves are expected to yield negative interocular correlations. Results: For both cVEPs and mfVEPs, the distribution of the correlation coefficients in the PCD patients yielded largely positive values and did not differ from the controls. Consequently, neither large nor small-scale lateralisation abnormalities were observed in PCD. Further, the optic nerve projection did not depend on the presence of situs inversus. Conclusions: The absence of evidence for projection abnormalities in a cohort of ten subjects with PCD, five of which had Kartagener syndrome, underlines that misrouting of the optic nerves is not a common trait of these subjects. |
| | |
Authors:
|
Michael B Hoffmann; Barbara Wolynski; Michael Bach; Synke Meltendorf; Wolfgang Behrens-Baumann; Franziska Golla |
Related Documents
:
|
9308059 - Orotracheal fibreoptic intubation in children under general anaesthesia. 18074669 - Dysphagia after chemoradiation: analysis by modified barium swallow. 8777379 - A comparison of direct, indirect, and fiberoptic laryngoscopy to evaluate vocal cord pa... 12707159 - Airway management using the intubating laryngeal mask airway for the morbidly obese pat... 10989859 - Variations in ilma external diameters: another cause of device failure. 19938199 - Unsedated transnasal small-caliber esophagogastroduodenoscopy in elderly and bedridden ... 9510639 - Diagnostic value of endometrial curettage in abnormal uterine bleeding--a histopatholog... 22305819 - Renal insufficiency and vascular complications after primary angioplasty via femoral ro... 11243639 - Increased basic fibroblast growth factor levels in serum and blister fluid from patient... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-20 |
Journal Detail:
|
Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Ophthalmology, Otto-von-Guericke-University Magdeburg, Leipziger Straße 44, 39120 Magdeburg, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mapping choroidal and retinal thickness variation in Type 2 diabetes using 3D-1060nm-OCT.
Next Document: Association between SRBD1 and ELOVL5 gene polymorphisms and primary open angle glaucoma.